1-Piperidinecarboxylic acid, 4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl] -2-oxoethyl]amino]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl] -2-oxoethyl]amino]-, 1,1-dimethylethyl ester
CAS No.:188786-08-5
Molecular Formula:C₃₁H₄₀Cl₂N₄O₄
Molecular Weight:603.589
Hs Code.:

1-Piperidinecarboxylic acid,
4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl]
-2-oxoethyl]amino]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl] -2-oxoethyl]amino]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl] -2-oxoethyl]amino]-, 1,1-dimethylethyl ester

There total 8 articles about 1-Piperidinecarboxylic acid, 4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl] -2-oxoethyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 499-06-9
3,5-dimethylbenzoic acid

: 188786-08-5
(-)-1,1-dimethylethyl 4-[[2-[2(R)-(3,4-dichlorophenyl)-1-(3,5-dimethylbenzoyl)-1-piperazinyl]-2-oxoethyl]amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: HOBT; Et₃N; DEC / 0 °C

2: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

3: (i-Pr)2NEt / CH₂Cl₂

With diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0960-894X(02)00645-5

Reference yield:

: 6725-44-6
methyl 2-(3,4-dichlorophenyl)acetate

: 188786-08-5
(-)-1,1-dimethylethyl 4-[[2-[2(R)-(3,4-dichlorophenyl)-1-(3,5-dimethylbenzoyl)-1-piperazinyl]-2-oxoethyl]amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: NBS

2.1: LAH / diethyl ether

2.2: N-acetyl-L-leucine

3.1: HOBT; Et₃N; DEC / 0 °C

4.1: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

5.1: (i-Pr)2NEt / CH₂Cl₂

With N-Bromosuccinimide; lithium aluminium tetrahydride; diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(02)00645-5

Reference yield:

: 163339-71-7
α-bromo-3,4-dichlorophenylacetic acid methyl ester

: 188786-08-5
(-)-1,1-dimethylethyl 4-[[2-[2(R)-(3,4-dichlorophenyl)-1-(3,5-dimethylbenzoyl)-1-piperazinyl]-2-oxoethyl]amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: LAH / diethyl ether

1.2: N-acetyl-L-leucine

2.1: HOBT; Et₃N; DEC / 0 °C

3.1: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

4.1: (i-Pr)2NEt / CH₂Cl₂

With lithium aluminium tetrahydride; diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(02)00645-5