Diphenyl 4-Bromo-alpha-chlorobenzylphosphonate

Base Information

• Chemical Name: Diphenyl 4-Bromo-alpha-chlorobenzylphosphonate
• CAS No.: 189099-56-7
• Molecular Formula: C₁₉H₁₅BrClO₃P
• Molecular Weight: 437.657
• Mol file: 189099-56-7.mol

Synonyms:D3875;Diphenyl 4-Bromo-α-chlorobenzylphosphonate;diphenyl chloro(4-bromophenyl)methylphosphonate;4-Bromo-α-chlorobenzylphosphonic Acid Diphenyl Ester;

Chemical Property of Diphenyl 4-Bromo-alpha-chlorobenzylphosphonate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 107°C(lit.)
• Boiling Point: 517.854oC at 760 mmHg
• Flash Point: 266.988oC
• PSA: 45.34000
• LogP: 7.03760

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diphenyl4-Bromo-α-chlorobenzylphosphonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diphenyl 4-Bromo-alpha-chlorobenzylphosphonate

There total 2 articles about Diphenyl 4-Bromo-alpha-chlorobenzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyl hydrogen phosphite (4712-55-4) → diphenyl chloro(4-bromophenyl)methylphosphonate (189099-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / Ambient temperature

2: POCl₃, N,N-diethylaniline / 1 h / 90 °C

With N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran;

DOI:10.1039/a606915k

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → diphenyl chloro(4-bromophenyl)methylphosphonate (189099-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / Ambient temperature

2: POCl₃, N,N-diethylaniline / 1 h / 90 °C

With N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran;

DOI:10.1039/a606915k

Reference yield: 26.0%

4-methoxy-benzaldehyde (123-11-5) + diphenyl chloro(4-bromophenyl)methylphosphonate (189099-56-7) → 1-bromo-4-[2-(4-methoxyphenyl)ethynyl]benzene (189099-57-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1039/a606915k

upstream raw materials:

diphenyl hydrogen phosphite

4-bromo-benzaldehyde

Downstream raw materials:

C₂₁H₂₃BrO

1-bromo-4-((4-fluorophenyl)ethynyl)benzene

1-bromo-4-[2-(4-methoxyphenyl)ethynyl]benzene

[4-(4-Bromo-phenylethynyl)-phenyl]-diethyl-amine

Refernces