METHYL 1-BENZOFURAN-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1-BENZOFURAN-2-CARBOXYLATE
• CAS No.: 1646-27-1
• Molecular Formula: C10H8 O3
• Molecular Weight: 176.172
• Hs Code.: 2932999099
• Mol file: 1646-27-1.mol

Synonyms:Coumarilicacid, methyl ester (6CI); 2-Carbomethoxybenzofuran;2-Methoxycarbonylbenzofuran; Methyl 2-benzofurancarboxylate; Methylbenzo[b]furan-2-carboxylate; Methyl coumarilate; NSC 156073

Chemical Property of METHYL 1-BENZOFURAN-2-CARBOXYLATE

Chemical Property:

• Melting Point: 54-55 °C
• Boiling Point: 257.7°Cat760mmHg
• Flash Point: 109.7°C
• PSA: 39.44000
• Density: 1.221g/cm³
• LogP: 2.21940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-Benzofuran-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-BENZOFURAN-2-CARBOXYLATE

There total 34 articles about METHYL 1-BENZOFURAN-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzofurane (271-89-6) + methanol (67-56-1) + tetrachloromethane (56-23-5) → methyl benzofuran-2-carboxylate (1646-27-1)

Guidance literature:

With iron(II) bromide; at 160 ℃; for 4h; regioselective reaction; Inert atmosphere; sealed ampule;

DOI:10.1134/S1070428011030195

Reference yield: 95.0%

Dimethyl (2-allyloxyphenyl)methylenemalonate (99558-32-4) → methyl benzofuran-2-carboxylate (1646-27-1)

Guidance literature:

at 650 ℃; under 0.001 - 0.01 Torr;

DOI:10.1039/c39930000959

Reference yield: 89.0%

1-benzofurane (271-89-6) + methanol (67-56-1) + Bromotrichloromethane (75-62-7) → methyl benzofuran-2-carboxylate (1646-27-1)

Guidance literature:

With ferrocene; at 140 ℃; for 4h; regioselective reaction; Inert atmosphere; sealed ampule;

DOI:10.1134/S1070428011030195

upstream raw materials:

methanol

Benzofuran-2-carboxylic acid

benzofuran-2-yl-phenyl ketone-[(Z)-O-(toluene-4-sulfonyl)-oxime ]

diazomethane

Downstream raw materials:

2-Benzofuranpropionic acid-β-oxo-ethylester

benzofuran-2-yl-methanol

3-(1-benzofuran-2-yl)-3-oxopropanenitrile

2-bromomethylbenzofuran