Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

Base Information

Chemical Name:Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate
CAS No.:189509-22-6
Molecular Formula:C12H20O5
Molecular Weight:244.288
Hs Code.:
DSSTox Substance ID:DTXSID20455119
Wikidata:Q82276990

Synonyms:Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate;189509-22-6;ETHYL 2-{8-HYDROXY-1,4-DIOXASPIRO[4.5]DECAN-8-YL}ACETATE;C12H20O5;DTXSID20455119;1,4-Dioxaspiro[4.5]decane-8-acetic acid, 8-hydroxy-, ethyl ester;MFCD22761954;AKOS015379593;DS-8865;PB41543;CS-0151612;C73628;EN300-704305;A880447;Ethyl2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

Suppliers and Price of Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 10 raw suppliers

Chemical Property of Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:244.13107373
Heavy Atom Count:17
Complexity:273

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1(CCC2(CC1)OCCO2)O

Technology Process of Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

There total 1 articles about Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 105-36-2
ethyl bromoacetate

: 189509-22-6
(8-hydroxy-1,4-dioxaspiro[4,5]dec-8-yl)-acetic acid ethyl ester

Guidance literature:: With zinc; In tetrahydrofuran; for 8h; Heating;
DOI:10.1002/jccs.200300071

Reference yield: 67.0%

: 189509-22-6
(8-hydroxy-1,4-dioxaspiro[4,5]dec-8-yl)-acetic acid ethyl ester

: 81053-18-1
2-(1-hydroxy-4-carbonylcyclohexyl) ethyl acetate

Guidance literature:: With water; acetic acid; at 90 ℃; for 12h;
DOI:10.1016/S0040-4020(97)00138-5

Reference yield:

: 189509-22-6
(8-hydroxy-1,4-dioxaspiro[4,5]dec-8-yl)-acetic acid ethyl ester

: rengyoside A

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / LiAlH / diethyl ether / 2.8 h / 20 °C / Heating

2: water; Dowex 50X₈-100 (H⁺ form) / 24 h / 20 °C

3: 47 percent / p-TsOH / 2 h / 20 °C

4: 100 mg / LS-Selectride / tetrahydrofuran / 3 h / -78 - 20 °C

5: 35 percent / pyridine / 2 h / 20 °C

6: K₂CO₃; MeOH / 3 h / 20 °C

7: 89.6 mg / hydrogen / Pd/C / ethanol / 3 h / 20 °C

8: Sulfolobus solfataricus crude homogenate / 75 °C

With pyridine; methanol; Dowex 50X₈-100 (H⁺ form); Sulfolobus solfataricus crude homogenate; water; hydrogen; potassium carbonate; toluene-4-sulfonic acid; lithium tri-sec-butyl(hydrido)borate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; 1: Reduction / 2: Hydrolysis / 3: Condensation / 4: Reduction / 5: Acetylation / 6: methanolysis / 7: Hydrogenolysis / 8: transglucosidation;
DOI:10.1016/S0040-4020(97)00138-5