2,3-Diphenylbutanedioic acid dimethyl ester

Base Information

• Chemical Name: 2,3-Diphenylbutanedioic acid dimethyl ester
• CAS No.: 19020-59-8
• Molecular Formula: C18H18O4
• Molecular Weight: 298.339
• Hs Code.: 2917399090
• Mol file: 19020-59-8.mol

Synonyms:Butanedioic acid,2,3-diphenyl-,dimethyl ester;HMS2882C03;Dimethyl 2,3-Diphenylsuccinate;2,3-diphenylsuccinic acid dimethyl ester;2,3-Diphenyl-bernsteinsaeure-dimethylester;

Chemical Property of 2,3-Diphenylbutanedioic acid dimethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 2.90000

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Diphenylbutanedioic acid dimethyl ester

There total 33 articles about 2,3-Diphenylbutanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6) → dimethyl α,α'-diphenylsuccinate (19020-59-8)

Guidance literature:

bromo-phenyl-acetic acid methyl ester; With zinc; In tetrahydrofuran; Heating;

With (3,5-dinitrophenyl)(4-methylpiperazin-1-yl)methanone; copper(I) bromide dimethylsulfide complex; In N,N-dimethyl acetamide; at 22 ℃; for 1h;

DOI:10.1039/b610218b

Reference yield: 82.0%

(1-methoxy-2-phenylvinyloxy)trimethylsilane (40195-27-5) + 1-((diphenylmethylene)amino)-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one → dimethyl α,α'-diphenylsuccinate (19020-59-8) + benzophenone azine (983-79-9) + methyl Nα-(diphenylmethylene)-DL-phenylglycinate (171181-53-6)

Guidance literature:

In acetonitrile; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201904971

Reference yield: 80.0%

benzeneacetic acid methyl ester (101-41-7) → dimethyl α,α'-diphenylsuccinate (19020-59-8)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at -45 ℃;

DOI:10.1055/s-0028-1088123

upstream raw materials:

diazomethane

meso-2,3-diphenylsuccinic acid

benzeneacetic acid methyl ester

phenacylacetophenone

Downstream raw materials:

2,3-diphenylbutane-1,4-diol

2,3-diphenylsuccinic acid

Refernces

• 1、 Bonetti, Andrea,Clerici, Francesca,Foschi, Francesca,Nava, Donatella,Pellegrino, Sara,Penso, Michele,Soave, Raffaella,Gelmi, Maria Luisa. "Syn/anti switching by specific heteroatom-titanium coordination in the Mannich-like synthesis of 2,3-diaryl-β-amino acid derivatives". supporting information. p. 3203 - 3209. Retrieved 2014/06/09.
• 2、 Su, Xianbin,Fox, David J.,Blackwell, David T.,Tanaka, Kiyotaka,Spring, David R.. "Copper catalyzed oxidation of organozinc halides". . p. 3883 - 3885. Retrieved 2007/10/03.