4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-

Base Information

Chemical Name:4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-
CAS No.:191218-42-5
Molecular Formula:C14H9FN2O
Molecular Weight:240.237
Hs Code.:
DSSTox Substance ID:DTXSID70443147
Nikkaji Number:J2.276.357A
Wikidata:Q82260859
Mol file:191218-42-5.mol

Synonyms:191218-42-5;2-(4-fluorophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-;SCHEMBL8092386;DTXSID70443147;2-(4-Fluorophenyl)-4H-pyrido[1,2-a]pyrimidine-4-one

Suppliers and Price of 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:240.06989108
Heavy Atom Count:18
Complexity:482

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC(=CC(=O)N2C=C1)C3=CC=C(C=C3)F

Technology Process of 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-

There total 11 articles about 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 201230-82-2
carbon monoxide

: 2-[2-(1-phenylethylidene)hydrazinyl]pyridine

: 191218-42-5
2-(4-fluorophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: With dimanganese decacarbonyl; In toluene; at 100 ℃; for 16h; under 760.051 Torr; Schlenk technique; Sealed tube;
DOI:10.1002/anie.201801111

Reference yield: 78.0%

: 504-29-0
2-aminopyridine

: 1736-31-8
ethyl 3-(4-fluorophenyl)propiolate

: 191218-42-5
2-(4-fluorophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: With silver trifluoromethane sulfate; In chlorobenzene; at 120 ℃; for 24h; regioselective reaction;
DOI:10.1016/j.tetlet.2016.11.079

Reference yield: 75.0%

: 201230-82-2
carbon monoxide

: C₁₃H₁₁FN₂

: 191218-42-5
2-(4-fluorophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; copper diacetate; palladium diacetate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 24h; under 760.051 Torr; Sealed tube;
DOI:10.1039/c5cc02631h