6,9-Dioxa-2,15-diazaheptadec-12-enedioic acid, 16-[(3-chloro-4-methoxyphenyl)methyl]-3-methyl-10-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-7-(2-methylpropyl)-5,8,14-trioxo-, 1-(1,1-dimethylethyl) 17-(2,2,2-trichloroethyl) ester, (3R,7S,10S,12E,16R)-

Base Information

• Chemical Name: 6,9-Dioxa-2,15-diazaheptadec-12-enedioic acid, 16-[(3-chloro-4-methoxyphenyl)methyl]-3-methyl-10-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-7-(2-methylpropyl)-5,8,14-trioxo-, 1-(1,1-dimethylethyl) 17-(2,2,2-trichloroethyl) ester, (3R,7S,10S,12E,16R)-
• CAS No.: 193071-09-9
• Molecular Formula: C42H54Cl4N2O10
• Molecular Weight: 888.71

Synonyms:

Chemical Property of 6,9-Dioxa-2,15-diazaheptadec-12-enedioic acid, 16-[(3-chloro-4-methoxyphenyl)methyl]-3-methyl-10-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-7-(2-methylpropyl)-5,8,14-trioxo-, 1-(1,1-dimethylethyl) 17-(2,2,2-trichloroethyl) ester, (3R,7S,10S,12E,16R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,9-Dioxa-2,15-diazaheptadec-12-enedioic acid, 16-[(3-chloro-4-methoxyphenyl)methyl]-3-methyl-10-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-7-(2-methylpropyl)-5,8,14-trioxo-, 1-(1,1-dimethylethyl) 17-(2,2,2-trichloroethyl) ester, (3R,7S,10S,12E,16R)-

There total 4 articles about 6,9-Dioxa-2,15-diazaheptadec-12-enedioic acid, 16-[(3-chloro-4-methoxyphenyl)methyl]-3-methyl-10-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-7-(2-methylpropyl)-5,8,14-trioxo-, 1-(1,1-dimethylethyl) 17-(2,2,2-trichloroethyl) ester, (3R,7S,10S,12E,16R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-3-(3-Chloro-4-methoxy-phenyl)-2-((2E,7E)-(5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-propionic acid 2,2,2-trichloro-ethyl ester (162599-95-3) + (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid (193071-07-7) → (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester (193071-09-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

allyl (2S)-2-Hydroxy-4-methylpentanoate (162465-33-0) → (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester (193071-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Pd(PPh₃)4, N-methylmorpholine / tetrahydrofuran / 25 °C

3: 95 percent / DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

With 4-methyl-morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

(R)-3-((tert-butoxycarbonyl)amino)butanoic acid (159991-23-8) → (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester (193071-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Pd(PPh₃)4, N-methylmorpholine / tetrahydrofuran / 25 °C

3: 95 percent / DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

With 4-methyl-morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(98)00682-9

upstream raw materials:

(R)-3-(3-Chloro-4-methoxy-phenyl)-2-((2E,7E)-(5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-propionic acid 2,2,2-trichloro-ethyl ester

(S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid

allyl (2S)-2-Hydroxy-4-methylpentanoate

(R)-3-((tert-butoxycarbonyl)amino)butanoic acid

Downstream raw materials:

(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-[(S)-1-((2R,3R)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

(S)-2-((R)-3-Amino-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

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