methyl (2S)-2-amino-3-(2-methoxyphenyl)propanoate

Base Information

Chemical Name:methyl (2S)-2-amino-3-(2-methoxyphenyl)propanoate
CAS No.:193546-34-8
Molecular Formula:C11H15NO3
Molecular Weight:209.245
Hs Code.:
DSSTox Substance ID:DTXSID601296755

Synonyms:193546-34-8;SCHEMBL16878911;DTXSID601296755;2-Methoxy-L-phenylalanine methyl ester

Suppliers and Price of methyl (2S)-2-amino-3-(2-methoxyphenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-amino-3-(2-methoxyphenyl)propanoate

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:209.10519334
Heavy Atom Count:15
Complexity:208

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1CC(C(=O)OC)N
Isomeric SMILES:COC1=CC=CC=C1C[C@@H](C(=O)OC)N

Technology Process of methyl (2S)-2-amino-3-(2-methoxyphenyl)propanoate

There total 9 articles about methyl (2S)-2-amino-3-(2-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: C₁₉H₁₇NO₅

: 193546-34-8
L-2-methoxyphenylalanine methyl ester

Guidance literature:: With hydrazine hydrate; In methanol; at 20 ℃; for 20h;

Reference yield: 77.0%

: 67-56-1
methanol

: 193546-31-5
(S)-2-amino-3-(2-methoxyphenyl)propanoic acid

: 193546-34-8
L-2-methoxyphenylalanine methyl ester

Guidance literature:: With thionyl chloride; at 40 ℃; for 3h;
DOI:10.1002/jhet.5570340321

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 193546-34-8
L-2-methoxyphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaOEt / 1.) EtOH, 2.) EtOH, 3 h

2: 94 percent / aq. NaOH / 6 h / Heating

3: 63 percent / Aspergillus acylase I, aq. KOH / 72 h / 40 °C

4: 77 percent / SOCl₂ / 3 h / 40 °C

With potassium hydroxide; sodium hydroxide; thionyl chloride; Aspergillus acylase I; sodium ethanolate;
DOI:10.1002/jhet.5570340321