2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE

Base Information

Chemical Name:2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE
CAS No.:193610-95-6
Molecular Formula:C9H11F3N2O
Molecular Weight:220.194
Hs Code.:
Mol file:193610-95-6.mol

Synonyms:2-t-butyl-4-hydroxy-6-trifluoromethylpyrimidine;2-(tert-Butyl)-6-(trifluoromethyl)pyrimidin-4-ol;2-(1,1-dimethylethyl)-6-trifluoromethylpyrimidin-4-ol;

Suppliers and Price of 2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4(3H)-pyrimidinone
250mg
$ 165.00

Crysdot
2-(tert-Butyl)-6-(trifluoromethyl)pyrimidin-4-ol 95+%
5g
$ 880.00

Chemenu
2-(tert-butyl)-6-(trifluoromethyl)pyrimidin-4-ol 95%
5g
$ 830.00

American Custom Chemicals Corporation
2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE 95.00%
5MG
$ 497.79

Alichem
2-(tert-Butyl)-6-(trifluoromethyl)pyrimidin-4-ol
5g
$ 932.40

Total 7 raw suppliers

Chemical Property of 2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE

Chemical Property:

Vapor Pressure:0.01mmHg at 25°C
Boiling Point:255.7oC at 760 mmHg
Flash Point:108.4oC
PSA：46.01000
Density:1.261g/cm3
LogP:2.49850
Storage Temp.:2-8°C
Solubility.:Chloroform, DCM

Purity/Quality:

97% ^*data from raw suppliers

2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4(3H)-pyrimidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4(3H)-pyrimidinone is an intermediate in the synthesis of ABT 925 Fumerate (A112600) is a dopamine D3 receptor antagonist that is used in the treatment of acute schizophrenia.

Technology Process of 2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE

There total 4 articles about 2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83643-84-9,488711-09-7
methyl 4,4,4-trifluoroacetoacetate

: 193610-95-6
2-(1,1-dimethylethyl)-6-trifluoromethylpyrimidin-4-ol

Guidance literature:: pivalamidine hydrochloride; With sodium methylate; In methanol; ethanol; at 20 ℃; for 0.5h;

methyl 4,4,4-trifluoroacetoacetate; In methanol; ethanol; at 78 ℃; for 3h;

Reference yield:

: 18202-73-8
pivalamidine hydrochloride

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 193610-95-6
2-(1,1-dimethylethyl)-6-trifluoromethylpyrimidin-4-ol

Guidance literature:: pivalamidine hydrochloride; ethyl 4,4,4-trifluoroacetoacetate; With sodium methylate; In methanol; at 80 ℃; for 16h; Reflux;

With hydrogenchloride; In methanol; water;