1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE

Base Information

• Chemical Name: 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE
• CAS No.: 17764-92-0
• Molecular Formula: C9H9 Br O2
• Molecular Weight: 229.073
• Hs Code.: 2914790090
• Mol file: 17764-92-0.mol

Synonyms:Propiophenone,4'-bromo-2'-hydroxy- (8CI)

Chemical Property of 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE

Chemical Property:

• Vapor Pressure: 0.000588mmHg at 25°C
• Melting Point: 48-49°C
• Boiling Point: 301.5°Cat760mmHg
• Flash Point: 136.1°C
• PSA: 37.30000
• Density: 1.506g/cm³
• LogP: 2.74740

Purity/Quality:

95% ^*data from raw suppliers

1-(4-Bromo-2-hydroxyphenyl)-1-propanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(4-Bromo-2-hydroxyphenyl)-1-propanone is a useful compound for preparation of indazoles.

Technology Process of 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE

There total 3 articles about 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-Bromophenol (591-20-8) + propionyl chloride (79-03-8) → 1-(4-bromo-2-hydroxyphenyl)-propan-1-one (17764-92-0)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; for 2h; Heating;

DOI:10.1055/s-1999-3431

Reference yield: 61.0%

3-bromophenyl propionic acid (23689-33-0) → 1-(4-bromo-2-hydroxyphenyl)-propan-1-one (17764-92-0)

Guidance literature:

With aluminum (III) chloride; Heating;

DOI:10.1039/c2ob25067e

Reference yield:

3-Bromophenol (591-20-8) → 1-(4-bromo-2-hydroxyphenyl)-propan-1-one (17764-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / benzene

2: AlCl₃

With pyridine; aluminium trichloride; In benzene;

upstream raw materials:

3-bromophenyl propionic acid

3-Bromophenol

propionyl chloride

Downstream raw materials:

1-(4-bromo-2-methoxyphenyl)propan-1-one

5-bromo-2-propionylphenyl methanesulfonate

3-Brom-6-<1-hydroxy-propyl>-anisol

2,3,4-Tribrom-6-<1-hydroxy-propyl>-anisol