(1,4-DIMETHYL-5-NITRO-1H-IMIDAZOL-2-YL)METHANOL

Base Information

• Chemical Name: (1,4-DIMETHYL-5-NITRO-1H-IMIDAZOL-2-YL)METHANOL
• CAS No.: 104575-39-5
• Molecular Formula: C₆H₉N₃O₃
• Molecular Weight: 171.156
• Hs Code.: 2933290090
• Mol file: 104575-39-5.mol

Synonyms:1,4-Dimethyl-2-hydroxymethyl-5-nitroimidazole

Chemical Property of (1,4-DIMETHYL-5-NITRO-1H-IMIDAZOL-2-YL)METHANOL

Chemical Property:

• Vapor Pressure: 1.54E-06mmHg at 25°C
• Boiling Point: 382.6°Cat760mmHg
• Flash Point: 185.2°C
• PSA: 83.87000
• Density: 1.46g/cm³
• LogP: 0.65220

Purity/Quality:

98%min ^*data from raw suppliers

(1,4-DIMETHYL-5-NITRO-1H-IMIDAZOL-2-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1,4-DIMETHYL-5-NITRO-1H-IMIDAZOL-2-YL)METHANOL

There total 1 articles about (1,4-DIMETHYL-5-NITRO-1H-IMIDAZOL-2-YL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,4-dimethyl-5-nitro-1H-imidazole (57658-79-4) → 1,4-dimethyl-2-(hydroxymethyl)-5-nitroimidazole (104575-39-5)

Guidance literature:

In dimethyl sulfoxide; at 125 ℃; for 67h;

DOI:10.1021/jm00384a025

Reference yield: 80.0%

1,4-dimethyl-2-(hydroxymethyl)-5-nitroimidazole (104575-39-5) → 1,4-dimethyl-5-nitro-1H-2-imidazolcarbaldehyde (499993-58-7)

Guidance literature:

With manganese(IV) oxide; In toluene; for 4h; Heating;

DOI:10.1021/jm021030a

Reference yield: 45.0%

1,4-dimethyl-2-(hydroxymethyl)-5-nitroimidazole (104575-39-5) + methyl carbamate (598-55-0) → 1,4-dimethyl-2-[(carbamoyloxy)methyl]-5-nitroimidazole (104575-24-8)

Guidance literature:

With di(n-butyl)tin oxide; at 150 ℃; for 5.5h;

DOI:10.1021/jm00384a025

upstream raw materials:

formaldehyd

1,4-dimethyl-5-nitro-1H-imidazole

Downstream raw materials:

1,4-dimethyl-2-[(carbamoyloxy)methyl]-5-nitroimidazole

1,4-dimethyl-5-nitro-1H-2-imidazolcarbaldehyde

Refernces

• 1、 Walsh,Wang,Bagan,Wislocki,Miwa. "Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles". . p. 150 - 156. Retrieved 2007/10/02.