TRANS-1-PHENYL-4-TERT-BUTYLCYCLOHEXANOL

Base Information

• Chemical Name: TRANS-1-PHENYL-4-TERT-BUTYLCYCLOHEXANOL
• CAS No.: 19437-01-5
• Molecular Formula: C16H24O
• Molecular Weight: 232.366
• Hs Code.: 2906299090
• Mol file: 19437-01-5.mol

Synonyms:4-Tert-butyl-1-phenylcyclohexanol;

Chemical Property of TRANS-1-PHENYL-4-TERT-BUTYLCYCLOHEXANOL

Chemical Property:

• PSA: 20.23000
• LogP: 4.11050

Purity/Quality:

99.90% ^*data from raw suppliers

4-TERT-BUTYL-1-PHENYLCYCLOHEXANOL AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-1-PHENYL-4-TERT-BUTYLCYCLOHEXANOL

There total 3 articles about TRANS-1-PHENYL-4-TERT-BUTYLCYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenyltriisopropoxytitanium(IV) (16635-23-7) + 4-tercbutyl-cyclohexanone (98-53-3) → 4-(tert-butyl)-1-phenylcyclohexanol (19437-01-5)

Guidance literature:

In tetrahydrofuran; for 15h; Ambient temperature;

DOI:10.1002/hlca.19810640136

Reference yield: 58.0%

iodobenzene (591-50-4) + 4-tercbutyl-cyclohexanone (98-53-3) → 4-(tert-butyl)-1-phenylcyclohexanol (19437-01-5)

Guidance literature:

With samarium diiodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; benzene; for 0.166667h; Ambient temperature;

DOI:10.1248/cpb.42.2190

Reference yield: 22.0%

4-tercbutyl-cyclohexanone (98-53-3) + phenylmagnesium bromide (100-58-3) → 4-(tert-butyl)-1-phenylcyclohexanol (19437-01-5)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.1c01264

upstream raw materials:

phenyltriisopropoxytitanium(IV)

4-tercbutyl-cyclohexanone

iodobenzene

phenylmagnesium bromide

Downstream raw materials:

1-phenyl-4-tert-butylcyclohexene

4-tert-butylbiphenyl

4-tercbutyl-cyclohexanone

Acetanilid