2-Phenylacetic acid 2-methylphenyl ester

Base Information

• Chemical Name: 2-Phenylacetic acid 2-methylphenyl ester
• CAS No.: 194420-43-4
• Molecular Formula: C15H14O2
• Molecular Weight: 226.27000
• Mol file: 194420-43-4.mol

Synonyms:Benzeneacetic acid,2-methyl-,phenyl ester;

Chemical Property of 2-Phenylacetic acid 2-methylphenyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 3.14310

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenylacetic acid 2-methylphenyl ester

There total 2 articles about 2-Phenylacetic acid 2-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

carbon monoxide (201230-82-2) + N,N,N-trimethyl-1-(o-tolyl)methanaminium trifluoromethanesulfonate + phenol (108-95-2,27073-41-2) → phenyl 2-(o-tolyl)acetate (194420-43-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triphenylphosphine; In toluene; at 100 ℃; for 10h; under 760.051 Torr; Schlenk technique;

DOI:10.1039/c8ob00488a

Reference yield:

N,N-dimethyl(2-methylbenzyl)amine (4525-48-8) → phenyl 2-(o-tolyl)acetate (194420-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 0.5 h / 0 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenylphosphine; sodium carbonate / toluene / 10 h / 100 °C / 760.05 Torr / Schlenk technique

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triphenylphosphine; In diethyl ether; toluene;

DOI:10.1039/c8ob00488a

Reference yield:

phenyl 2-(o-tolyl)acetate (194420-43-4) → (benzyloxy)benzene (946-80-5) + 1,1'-(1,2-ethanediyl)bisbenzene (103-29-7) + 1-(4-Hydroxy-phenyl)-2-o-tolyl-ethanone + 1-(2-Hydroxy-phenyl)-2-o-tolyl-ethanone + phenol (108-95-2,27073-41-2)

Guidance literature:

In acetonitrile; Product distribution; Mechanism; Ambient temperature; Irradiation;

upstream raw materials:

N,N-dimethyl(2-methylbenzyl)amine

carbon monoxide

phenol

Downstream raw materials:

(benzyloxy)benzene

1,1'-(1,2-ethanediyl)bisbenzene

phenol

Refernces