N-(3-bromo-4-methoxyphenyl)Acetamide

Base Information

• Chemical Name: N-(3-bromo-4-methoxyphenyl)Acetamide
• CAS No.: 6943-73-3
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.088
• Mol file: 6943-73-3.mol

Synonyms:Essigsaeure-(3-brom-4-methoxy-anilid);N-(3-BROMO-4-METHOXY-PHENYL)ACETAMIDE;acetic acid-(3-bromo-4-methoxy-anilide);3-bromo-4-methoxyacetanilide;2-bromo-4-acetaminoanisole;2-Brom-4-acetamino-anisol;2-Brom-4-acetamino-phenol-methylaether;

Chemical Property of N-(3-bromo-4-methoxyphenyl)Acetamide

Chemical Property:

• Vapor Pressure: 5.44E-06mmHg at 25°C
• Boiling Point: 380.5°Cat760mmHg
• Flash Point: 183.9°C
• PSA: 38.33000
• Density: 1.5g/cm³
• LogP: 2.48910

Purity/Quality:

N-(3-bromo-4-methoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-bromo-4-methoxyphenyl)Acetamide

There total 7 articles about N-(3-bromo-4-methoxyphenyl)Acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(3-bromo-4-hydroxyphenyl)acetamide (6329-78-8) + methyl iodide (74-88-4) → N-(3-bromo-4-methoxyphenyl)acetamide (6943-73-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 6h; Inert atmosphere;

DOI:10.1039/b924619c

Reference yield: 95.0%

3-bromo-p-anisidine (19056-41-8) + acetic anhydride (108-24-7) → N-(3-bromo-4-methoxyphenyl)acetamide (6943-73-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2008.02.080

Reference yield: 91.0%

4-methoxyacetanilide (51-66-1) → N-(3-bromo-4-methoxyphenyl)acetamide (6943-73-3)

Guidance literature:

With hydrogen bromide; Selectfluor; In water; at 20 ℃; for 0.25h; regioselective reaction;

DOI:10.1016/j.tetlet.2016.10.092

upstream raw materials:

3-bromo-p-anisidine

4-methoxyacetanilide

acetic acid

2-bromo-4-nitroanisole

Downstream raw materials:

N-(5-bromo-4-methoxy-2-nitrophenyl)acetamide

5-bromo-6-methoxy-8-nitroquinoline

6-methoxy-5-phenoxy-[8]quinolylamine

6-methoxy-5-(4-methoxy-phenoxy)-[8]quinolylamine