N-Cyclohexylpyridin-2-amine

Base Information

• Chemical Name: N-Cyclohexylpyridin-2-amine
• CAS No.: 15513-16-3
• Molecular Formula: C11H16 N2
• Molecular Weight: 176.261
• Hs Code.: 2933399090
• European Community (EC) Number: 239-541-4
• NSC Number: 158621
• DSSTox Substance ID: DTXSID50165815
• Nikkaji Number: J317.948F
• Wikidata: Q83035043
• Mol file: 15513-16-3.mol

Synonyms:N-Cyclohexylpyridin-2-amine;15513-16-3;2-Pyridinamine, N-cyclohexyl-;EINECS 239-541-4;Cyclohexyl-pyridin-2-yl-amine;NSC158621;2-Pyridylcyclohexylamine;cyclohexyl-2-pyridylamine;Maybridge4_000670;N(C1CCCCC1)c2ccccn2;cyclohexyl-2-pyridinylamine;Oprea1_724039;Oprea1_762632;SCHEMBL1579641;2-CYCLOHEXYLAMINOPYRIDINE;DTXSID50165815;HMS1522O10;CCG-54948;STL352708;AKOS000115530;NSC 158621;NSC-158621;IDI1_031252;CS-0218875;EN300-02351;SR-01000644005-1;BRD-K32406882-001-01-7;Z31198083;F0273-0039

Chemical Property of N-Cyclohexylpyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.000745mmHg at 25°C
• Melting Point: 125-126 °C
• Boiling Point: 307°Cat760mmHg
• PKA: 6?+-.0.10(Predicted)
• Flash Point: 139.5°C
• PSA: 24.92000
• Density: 1.07g/cm³
• LogP: 2.89920
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.131348519
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-cyclohexylpyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NC2=CC=CC=N2

Technology Process of N-Cyclohexylpyridin-2-amine

There total 12 articles about N-Cyclohexylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloropyridine (109-09-1) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylpyridin-2-amine (15513-16-3)

Guidance literature:

With (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; sodium t-butanolate; palladium diacetate; In 1,2-dimethoxyethane; at 70 ℃; for 12h;

DOI:10.1002/anie.200462629

Reference yield: 96.0%

2-bromo-pyridine (109-04-6) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylpyridin-2-amine (15513-16-3)

Guidance literature:

With sodium t-butanolate; palladium diacetate; (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; In 1,2-dimethoxyethane; at 60 ℃; for 12h;

DOI:10.1021/ja077074w

Reference yield: 92.0%

N-cyclohexyl-2,2-difluoro-2-(pyridin-2-ylsulfonyl)acetamide → N-cyclohexylpyridin-2-amine (15513-16-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 60 ℃; for 3h;

DOI:10.1002/adsc.201500150

upstream raw materials:

pyridine

cyclohexylamine

2-aminopyridine

cyclohexanone

Downstream raw materials:

N-cyclohexyl-N-pyridin-2-yl-benzamide

2-(N-chlorocarbonyl-N-cyclohexyl)aminopyridine

2-(N-cyclohexyl-N-ethoxycarbonyl)aminopyridine

N-cyclohexyl-N-(pyridin-2-yl)-N'-(4-nitrophenyl)urea