CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-

Base Information

Chemical Name:CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-
CAS No.:194788-06-2
Molecular Formula:C24H24N4O2
Molecular Weight:400.47300
Hs Code.:
Mol file:194788-06-2.mol

Synonyms:

Suppliers and Price of CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(trans-3-(4-Amino-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclobutyl)methanol 95%
1g
$ 1342.00

American Custom Chemicals Corporation
(TRANS-3-(4-AMINO-5-(3-(BENZYLOXY)PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)CYCLOBUTYL)METHANOL 95.00%
5MG
$ 503.81

Total 3 raw suppliers

Chemical Property of CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-

Chemical Property:

PSA：86.19000
LogP:4.78410

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

(trans-3-(4-Amino-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclobutyl)methanol 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-

There total 26 articles about CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 952138-97-5
2-amino-1-[cis-3-(hydroxymethyl)cyclobutyl]-4-[3-(phenylmethoxy)phenyl]-1H-pyrrole-3-carbonitrile

: 3473-63-0
formamidine acetic acid

: 194788-06-2
3-[4-amino-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cis-cyclobutane methanol

Guidance literature:: at 120 ℃; for 5h; Inert atmosphere;
DOI:10.1021/op700052u

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 194788-06-2
3-[4-amino-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cis-cyclobutane methanol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / Inert atmosphere

2: bromine; Pyridine hydrobromide / Inert atmosphere

3: hydrogenchloride; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

4: Inert atmosphere

5: 5 h / 120 °C / Inert atmosphere

With hydrogenchloride; bromine; Pyridine hydrobromide; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/op700052u

Reference yield:

: cis-3-aminocyclobutanemethyl benzoate butanedioate

: 194788-06-2
3-[4-amino-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cis-cyclobutane methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethyl acetate; water; acetonitrile / 0.17 h / 20 - 25 °C / Inert atmosphere

1.2: -16 - -10 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate; water; acetonitrile / 1 h / -16 - -10 °C / Inert atmosphere

3.1: potassium hydroxide / water; methanol / 0.92 h / 22 °C / Inert atmosphere; Reflux

4.1: 5 h / 120 °C / Inert atmosphere

With hydrogenchloride; potassium hydroxide; sodium hydroxide; In methanol; water; ethyl acetate; acetonitrile;
DOI:10.1021/op700052u