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Usage

Uses

Used in Pharmaceutical Development:
N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure and functional groups may contribute to the development of new medications with specific therapeutic properties.
Used in Chemical Research:
In the field of chemical research, N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine is used as a compound of interest for studying its reactivity and potential applications in various chemical reactions. Its properties may provide insights into new reaction pathways or the creation of novel chemical products.
Used in Specialty Chemical Products:
N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine is used as a key component in the formulation of specialty chemical products. Its unique combination of functional groups may offer advantages in the performance or properties of these products, such as improved stability or enhanced reactivity.

InChI:InChI=1/C19H24ClNO4/c1-23-15-7-4-13(5-8-15)16(22)12-21-11-10-14-6-9-17(24-2)19(25-3)18(14)20/h4-9,16,21-22H,10-12H2,1-3H3

Upstream product

• 6388-72-3 2-(4-methoxyphenyl)oxirane 
• 67287-36-9 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 901773-06-6 C₁₉H₂₂ClNO₄ 
• 81316-63-4 ethyl (2-chloro-3,4-dimethoxyphenyl)acetimidate hydrochloride 
• 55275-61-1 2-amino-1-(4-methoxyphenyl)ethanol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 72912-33-5 2-bromo-1-(tert-butoxy)-1-(4-methoxyphenyl)ethane 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 7537-07-7 2-(2-chloro-3,4-dimethoxyphenyl)acetonitrile 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 19484-05-0 1-((4-methoxy)phenyl)-1,2-dibromoethane 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 

Downstream Products

• 67227-56-9 fenoldopam 
• 93983-15-4 6-chloro-7,8-dimethoxy-1-(4'-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 
• 67287-53-0 6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 104113-95-3 6-Chloro-1-(4-hydroxy-phenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide 
• 67287-54-1 Fenoldopam hydrobromide 
• 87863-72-7 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-methyl-1H-3-benzazepine-7,8-diol 
• 100166-60-7 6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carbaldehyde 

Relevant academic research and scientific papers

Process for the preparation of Fenoldopam Mesylate

Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.

Solid oral preparation containing a pyrrolidine derivative with a catechol group

An oral solid preparation comprising an organic acid or its salt and a catechol compound. The catechol compound is, for example, a pyrrolidine derivative having a catechol group of the following general formula (I). It exhibits an improved absorbability in vivo. STR1

Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines

New intermediates, namely 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines, are prepared by a synthetic sequence which uses a Darzen's reaction in a homogeneous solvent system.

Process for preparing secondary amines

New intermediates and processes for preparing 6-halo-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines involve the reaction of a p-methoxyphenylglyoxal, lower alkyl hemimercaptal with a 2-chloro-3,4-dimethoxyphenethylamine, followed by a borohydride reduction.

Oxazolines. 2. 2-Substituted 2-Oxazolines as Synthons for N-(β-Hydroxyethyl)arylalkylamines, Intermediates in a Synthesis of 1,2,3,4-Tetrahydroisoquinolines and 2,3,4,5-Tetrahydro-1H-3-Benzazepines

2-(Arylalkyl)-2-oxazolines 4 (n = 1) and 2-aryl-2-oxazolines 4 (n = 0), the latter prepared in a novel reaction by cross-coupling aryl Grignard reagents with 2-(methylthio)-5-phenyl-2-oxazoline (10) and using palladium(II) chloride (14) as a catalyst, were reduced in a previously unreported reaction by diborane in refluxing THF to yield N-(β- hyroxyethyl)arylalkylamines 5 (n = 1,2).Amino alcohols 5 were cyclized to their respective heterocyclic derivatives 6 (n = 1,2) by treatment with H2SO4/TFA in refluxing methylene chloride.This paper disscuses how 2-substituted 2-oxazolines may be used to prepare1,2,3,4-tetrahydroisoquinolines 6 (n = 1) and 2,3,4,5-tetrahydro-1H-3-benzazepines 6 (n = 2) via amino alcohols 5.

Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines have dopaminergic activity. Examples of leading species of the invention are 6,9-dichloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9-dichloro-7,8-dihydroxy-1-(p-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine in the form of an acid addition salt.