10H-Phenothiazine-10-propanenitrile

Base Information

• Chemical Name: 10H-Phenothiazine-10-propanenitrile
• CAS No.: 1698-80-2
• Molecular Formula: C15H12 N2 S
• Molecular Weight: 252.34
• Hs Code.: 2934300000
• Mol file: 1698-80-2.mol

Synonyms:Phenothiazine-10-propionitrile(6CI,7CI,8CI); 10-(2-Cyanoethyl)phenothiazine;3-(Phenothiazin-10-yl)propanenitrile; NSC 139052; NSC 21556

Chemical Property of 10H-Phenothiazine-10-propanenitrile

Chemical Property:

• Vapor Pressure: 3.02E-08mmHg at 25°C
• Melting Point: 158-159 °C
• Boiling Point: 448.8°Cat760mmHg
• PKA: -0.33±0.20(Predicted)
• Flash Point: 225.2°C
• PSA: 52.33000
• Density: 1.236g/cm³
• LogP: 4.26798
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly, Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Phenothiazine-10-propionitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 10H-Phenothiazine-10-propanenitrile is a reagent used in the addition of Phenothiazine (P318040).

Technology Process of 10H-Phenothiazine-10-propanenitrile

There total 3 articles about 10H-Phenothiazine-10-propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

10H-phenothiazine (92-84-2) + acrylonitrile (107-13-1,25014-41-9) → 10H-phenothiazine-10-propanenitrile (1698-80-2)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In 1,4-dioxane; water; for 1h; Heating;

DOI:10.1021/ol006303f

Reference yield: 40.0%

10H-phenothiazine (92-84-2) + bromopropionitrile (2417-90-5) → 10H-phenothiazine-10-propanenitrile (1698-80-2)

Guidance literature:

10H-phenothiazine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

bromopropionitrile; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

→ 10H-phenothiazine-10-propanenitrile (1698-80-2)

Guidance literature:

Phenothiazin, Acrylnitril;

upstream raw materials:

10H-phenothiazine

acrylonitrile

bromopropionitrile

Downstream raw materials:

prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyl-N'-prop-2-ynyltyrosinamide

prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyltyrosinate

N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

Refernces

• 1、 Cummins, David,Boschloo, Gerrit,Ryan, Michael,Corr, David,Rao, S. Nagaraja,Fitzmaurice, Donald. "Ultrafast electrochromic windows based on redox-chromophore modified nanostructured semiconducting and conducting films". . p. 11449 - 11459. Retrieved 2000.
• 2、 Sch?fgen, Bj?rn,Khelwati, Hilla,Bechtel, Dominique F.,Decuyper, Annelies,Schüssler, Axel,Neuba, Adam,Pierik, Antonio J.,Ernst, Stefan,Müller, Thomas J. J.,Thiel, Werner R.. "Phenothiazine electrophores immobilized on periodic mesoporous organosilicas by ion exchange". . p. 16396 - 16410. Retrieved 2019.
• 3、 Harfenist,M.. "-". . p. 1834 - 1837. Retrieved 1963.
• 4、 Thiyagarajan, Subramanian,Krishnakumar, Varadhan,Gunanathan, Chidambaram. "KOtBu-Catalyzed Michael Addition Reactions Under Mild and Solvent-Free Conditions". supporting information. p. 518 - 523. Retrieved 2020/02/04.