alpha-Amino-beta-benzoylpropionic acid

Base Information

• Chemical Name: alpha-Amino-beta-benzoylpropionic acid
• CAS No.: 15121-92-3
• Molecular Formula: C10H11 N O3
• Molecular Weight: 193.202
• Mol file: 15121-92-3.mol

Synonyms:Alanine,3-benzoyl- (7CI,8CI); FCE 27377; a-Amino-b-benzoylpropionicacid

Chemical Property of alpha-Amino-beta-benzoylpropionic acid

Chemical Property:

• PSA: 80.39000
• LogP: 1.37160

Purity/Quality:

97% ^*data from raw suppliers

ALPHA-AMINO-BETA-BENZOYLPROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-Amino-beta-benzoylpropionic acid

There total 14 articles about alpha-Amino-beta-benzoylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61%

t-butyl 2-(t-butoxycarbonylamino)-4-oxo-4-phenylbutanoate (111717-08-9) → α-amino-γ-oxo-(+/-)-benzenebutanoic acid (15121-92-3)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 0.25h; Heating;

DOI:10.1016/S0040-4020(01)86046-4

Reference yield:

1-styrenyloxytrimethylsilane (13735-81-4) → α-amino-γ-oxo-(+/-)-benzenebutanoic acid (15121-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 37 percent / titanium tetrachloride / CH₂Cl₂ / 3 h / -78 °C

2: 0.1 M hydrochloric acid / H₂O / 3 h / Ambient temperature

3: 20 percent lithium hydroxide / H₂O / Ambient temperature

With hydrogenchloride; lithium hydroxide; titanium tetrachloride; In dichloromethane; water;

DOI:10.1016/S0040-4020(01)86045-2

Reference yield:

α-Amino-β-benzoyl-propionsaeure-ethylester → α-amino-γ-oxo-(+/-)-benzenebutanoic acid (15121-92-3)

Guidance literature:

With lithium hydroxide; In water; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)86045-2

upstream raw materials:

3-benzoylacrylic acid

diethyl 2-acetylamino-2-(2-oxo-2-phenylethyl)malonate

α-bromoacetophenone

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

benzyloxycarbonyl-DL-phenacylglycine

Refernces

• 1、 O'Donell, Martin J.,Benett, William D.. "THE SYNTHESIS OF AMINO ACIDS BY REACTION OF AN ELECTROPHILIC GLYCINE CATION EQUIVALENT WITH NEUTRAL CARBON NUCLEOPHILES". . p. 5389 - 5402. Retrieved 2007/10/02.
• 2、 Veronese,Boccu',Benassi,Scoffone. "Preferential hydrolysis of kynurenine peptides.". . p. 294 - 300. Retrieved 2007/10/06.