Cinnoline, 4-chloro-6-methoxy-7-(phenylmethoxy)-, monohydrochloride

Base Information

• Chemical Name: Cinnoline, 4-chloro-6-methoxy-7-(phenylmethoxy)-, monohydrochloride
• CAS No.: 197359-42-5
• Molecular Formula: C16H13ClN2O2.ClH
• Molecular Weight: 337.205
• Mol file: 197359-42-5.mol

Synonyms:

Chemical Property of Cinnoline, 4-chloro-6-methoxy-7-(phenylmethoxy)-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cinnoline, 4-chloro-6-methoxy-7-(phenylmethoxy)-, monohydrochloride

There total 2 articles about Cinnoline, 4-chloro-6-methoxy-7-(phenylmethoxy)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (75665-73-5) + 6-methoxy-7-benzyloxy-4-hydroxycinnoline (197359-43-6) → 7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (197359-42-5)

Guidance literature:

With sulfuric acid; triethylamine; sodium nitrite; In thionyl chloride; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

6-methoxy-7-benzyloxy-4-hydroxycinnoline (197359-43-6) → 7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (197359-42-5)

Guidance literature:

In thionyl chloride; N,N-dimethyl-formamide;

Reference yield:

7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (197359-42-5) + 4-chloro-2-fluoro-5-hydroxyaniline (84478-72-8) → 7-benzyloxy-4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxycinnoline (770691-00-4)

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

6-methoxy-7-benzyloxy-4-hydroxycinnoline

Downstream raw materials:

7-benzyloxy-4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxycinnoline

Refernces

• 1、 -. "Cinnoline derivatives and use as medicine". . . Retrieved 2008/06/13.