tert-Butyl 4-[acetyl(Methyl)aMino]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-[acetyl(Methyl)aMino]piperidine-1-carboxylate
• CAS No.: 197727-57-4
• Molecular Formula: C13H24N2O3
• Molecular Weight: 256.34100
• Hs Code.: 2933399090
• Mol file: 197727-57-4.mol

Synonyms:tert-butyl 4-[acetyl(methyl)amino]piperidine-1-carboxylate;

Chemical Property of tert-Butyl 4-[acetyl(Methyl)aMino]piperidine-1-carboxylate

Chemical Property:

• PSA: 49.85000
• LogP: 1.80210

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl 4-[acetyl(methyl)amino]-piperidine-1-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-[acetyl(Methyl)aMino]piperidine-1-carboxylate

There total 2 articles about tert-Butyl 4-[acetyl(Methyl)aMino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetyl chloride (75-36-5) + 4-methylamino-piperidine-1-carboxylic acid tert-butyl ester (147539-41-1) → 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (197727-57-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

Reference yield: 50.0%

acetic anhydride (108-24-7) + 4-methylamino-piperidine-1-carboxylic acid tert-butyl ester (147539-41-1) → 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (197727-57-4)

Guidance literature:

In acetic acid;

Reference yield:

4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (197727-57-4) → 4-(N-acetyl-N-methylamino)-piperidine (83180-55-6)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 16h;

upstream raw materials:

acetyl chloride

4-methylamino-piperidine-1-carboxylic acid tert-butyl ester

acetic anhydride

Downstream raw materials:

4-(N-acetyl-N-methylamino)-piperidine