N-(4-Fluorobenzoyl)morpholine

Base Information

• Chemical Name: N-(4-Fluorobenzoyl)morpholine
• CAS No.: 1978-65-0
• Molecular Formula: C11H12FNO2
• Molecular Weight: 209.22
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10336286
• Nikkaji Number: J2.707.760I
• Wikidata: Q72479245
• ChEMBL ID: CHEMBL1736582
• Mol file: 1978-65-0.mol

Synonyms:1978-65-0;N-(4-FLUOROBENZOYL)MORPHOLINE;(4-Fluorophenyl)(morpholino)methanone;(4-fluorophenyl)-morpholin-4-ylmethanone;(4-Fluoro-phenyl)-morpholin-4-yl-methanone;4-(4-Fluorobenzoyl)morpholine;4-Fluorobenzoic acid, morpholide;thanone;Morpholine, 4-(4-fluorobenzoyl)-;Cambridge id 5119235;MLS000764826;SCHEMBL5208543;4-(4-Fluorobenzoyl)-morpholine;CHEMBL1736582;DTXSID10336286;HMS2681B19;MFCD00451910;STK174432;(4-Fluoro-phenyl)-morpholin-4-yl-me;AKOS000672815;SDCCGMLS-0064650.P001;4-[(4-Fluorophenyl)carbonyl]morpholine;BS-21909;SMR000290431;(4-fluorophenyl)(morpholin-4-yl)methanone;CS-0207018;FT-0709564

Chemical Property of N-(4-Fluorobenzoyl)morpholine

Chemical Property:

• Vapor Pressure: 3.98E-05mmHg at 25°C
• Boiling Point: 351.9oC at 760 mmHg
• PKA: -1.52±0.20(Predicted)
• Flash Point: 166.6oC
• PSA: 29.54000
• Density: 1.232g/cm3
• LogP: 1.23600
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 209.08520679
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

97% ^*data from raw suppliers

(4-Fluorophenyl)(morpholino)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)C2=CC=C(C=C2)F

Technology Process of N-(4-Fluorobenzoyl)morpholine

There total 24 articles about N-(4-Fluorobenzoyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C11H12BF4NO → 4-(4-fluorobenzoyl)morpholine (1978-65-0)

Guidance literature:

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1039/d0sc01330g

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + carbon monoxide (201230-82-2) + 1-Bromo-4-fluorobenzene (460-00-4) → 4-(4-fluorobenzoyl)morpholine (1978-65-0)

Guidance literature:

With potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 105 ℃; for 12h; under 3000.3 Torr;

DOI:10.1021/cs400232b

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + 4-fluorobenzaldehyde (459-57-4) → 4-(4-fluorobenzoyl)morpholine (1978-65-0)

Guidance literature:

morpholine; With C₁₂H₃₀NaO₆⁽¹⁺⁾*C₅₆H₈₄O₄Sm^(1-); In tetrahydrofuran; for 0.5h; Inert atmosphere;

4-fluorobenzaldehyde; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo802617d

upstream raw materials:

morpholine

4-fluorobenzaldehyde

4-Fluorobenzoic acid

carbon monoxide

Downstream raw materials:

(4-fluorophenyl)(1H-pyrrol-2-yl)methanone

ethyl {2-[(4-fluorophenyl)carbonyl]-1H-pyrrol-1-yl}acetate

5-(4-(N-Acetylaminophenyl))-10,20-bis(4-fluorophenyl)-15-(4-(methoxycarbonylphenyl)) porphyrin

15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin