15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin

Base Information

• Chemical Name: 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin
• CAS No.: 1443667-07-9
• Molecular Formula: C₄₆H₃₁F₂N₅O₂
• Molecular Weight: 723.781
• Mol file: 1443667-07-9.mol

Synonyms:15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin

Chemical Property of 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin

There total 5 articles about 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate (1443667-05-7) → 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin (1443667-07-9)

Guidance literature:

With ammonia; tin(ll) chloride; In hydrogenchloride; water; for 2h; Reflux; Inert atmosphere; liquid HCl;

DOI:10.1039/c3dt50711d

Reference yield:

1,9-bis(4-fluorobenzoyl)-5-(4-nitrophenyl)dipyrromethane (1443667-03-5) → 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin (1443667-07-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; ammonium chloride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / trifluoroacetic acid; acetonitrile; N,N-dimethyl-formamide / 1 h / 0 °C / Sonication

3: tin(ll) chloride; ammonia / hydrogenchloride; water / 2 h / Reflux; Inert atmosphere; liquid HCl

With sodium tetrahydroborate; ammonia; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tin(ll) chloride; In tetrahydrofuran; hydrogenchloride; methanol; water; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;

DOI:10.1039/c3dt50711d

Reference yield:

4-(4-fluorobenzoyl)morpholine (1978-65-0) → 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin (1443667-07-9)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate; sodium acetate / 1,2-dichloro-ethane / 6 h / 65 °C / Inert atmosphere; Reflux

2: sodium tetrahydroborate; ammonium chloride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / trifluoroacetic acid; acetonitrile; N,N-dimethyl-formamide / 1 h / 0 °C / Sonication

4: tin(ll) chloride; ammonia / hydrogenchloride; water / 2 h / Reflux; Inert atmosphere; liquid HCl

With sodium tetrahydroborate; ammonia; sodium acetate; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tin(ll) chloride; trichlorophosphate; In tetrahydrofuran; hydrogenchloride; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;

DOI:10.1039/c3dt50711d

upstream raw materials:

1,9-bis(4-fluorobenzoyl)-5-(4-nitrophenyl)dipyrromethane

4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate

4-Fluorobenzoic acid

4-(4-fluorobenzoyl)morpholine

Downstream raw materials:

C₉₉H₇₃F₂N₉O₅

[15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl) porphyrinato]zinc(II)

5-(4-(N-Acetylaminophenyl))-10,20-bis(4-fluorophenyl)-15-(4-(methoxycarbonylphenyl)) porphyrin