4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate

Base Information

• Chemical Name: 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate
• CAS No.: 1443667-05-7
• Molecular Formula: C₄₆H₂₉F₂N₅O₄
• Molecular Weight: 753.764
• Mol file: 1443667-05-7.mol

Synonyms:

Chemical Property of 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate

There total 4 articles about 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.5%

1,9-bis(4-fluorobenzoyl)-5-(4-nitrophenyl)dipyrromethane-dicarbinol + 5-(4-carbomethoxyphenyl)dipyrromethane (167482-99-7) → 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate (1443667-05-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid; at 0 ℃; for 1h; Sonication;

DOI:10.1039/c3dt50711d

Reference yield:

1,9-bis(4-fluorobenzoyl)-5-(4-nitrophenyl)dipyrromethane (1443667-03-5) → 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate (1443667-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; ammonium chloride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / trifluoroacetic acid; acetonitrile; N,N-dimethyl-formamide / 1 h / 0 °C / Sonication

With sodium tetrahydroborate; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;

DOI:10.1039/c3dt50711d

Reference yield:

4-Fluorobenzoic acid (456-22-4) → 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate (1443667-05-7)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane; thionyl chloride / 0.17 h / 0 - 20 °C / Reflux

2: trichlorophosphate; sodium acetate / 1,2-dichloro-ethane / 6 h / 65 °C / Inert atmosphere; Reflux

3: sodium tetrahydroborate; ammonium chloride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / trifluoroacetic acid; acetonitrile; N,N-dimethyl-formamide / 1 h / 0 °C / Sonication

With sodium tetrahydroborate; sodium acetate; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; In tetrahydrofuran; methanol; thionyl chloride; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;

DOI:10.1039/c3dt50711d

upstream raw materials:

1,9-bis(4-fluorobenzoyl)-5-(4-nitrophenyl)dipyrromethane

5-(4-carbomethoxyphenyl)dipyrromethane

4-Fluorobenzoic acid

4-(4-fluorobenzoyl)morpholine

Downstream raw materials:

15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin

5-(4-(N-Acetylaminophenyl))-10,20-bis(4-fluorophenyl)-15-(4-(methoxycarbonylphenyl)) porphyrin