Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]-

Base Information

Chemical Name:Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]-
CAS No.:201813-47-0
Molecular Formula:C17H12F3NO2
Molecular Weight:319.283
Hs Code.:
DSSTox Substance ID:DTXSID90441221
Nikkaji Number:J1.907.320C

Synonyms:Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]-;201813-47-0;DTXSID90441221;N-[2-(4-Methoxyphenylethynyl)phenyl]trifluoroacetamide

Suppliers and Price of Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]-

Chemical Property:

PSA：41.82000
LogP:4.24530
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:319.08201311
Heavy Atom Count:23
Complexity:469

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C#CC2=CC=CC=C2NC(=O)C(F)(F)F

Technology Process of Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]-

There total 5 articles about Acetamide, 2,2,2-trifluoro-N-[2-[(4-methoxyphenyl)ethynyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 157869-15-3
2-((4-methoxyphenyl)ethynyl)aniline

: 407-25-0
trifluoroacetic anhydride

: 201813-47-0
2,2,2-trifluoro-N-(2-((4-methoxyphenyl)ethynyl)phenyl)acetamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo1005119

Reference yield: 58.0%

: 143321-89-5
2,2,2-trifluoro-N-(2-iodophenyl)acetamide

: 768-60-5
4-methoxyphenylacetylen

: 201813-47-0
2,2,2-trifluoro-N-(2-((4-methoxyphenyl)ethynyl)phenyl)acetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tetlet.2020.151896

Reference yield: 10.0%

: 143321-89-5
2,2,2-trifluoro-N-(2-iodophenyl)acetamide

: 768-60-5
4-methoxyphenylacetylen

: 5784-95-2
2-(4-methoxyphenyl)-1H-indole

: 201813-47-0
2,2,2-trifluoro-N-(2-((4-methoxyphenyl)ethynyl)phenyl)acetamide

Guidance literature:: With potassium phosphate; copper(l) iodide; triphenylphosphine; In 1,4-dioxane; at 110 ℃; for 24h;
DOI:10.1021/ol035378r