1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile

Base Information

Chemical Name:1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile
CAS No.:28799-82-8
Molecular Formula:C9H10 N2 O3
Molecular Weight:194.19
Hs Code.:
European Community (EC) Number:249-231-0
DSSTox Substance ID:DTXSID80951440
Nikkaji Number:J286.458D
Wikidata:Q82929760
ChEMBL ID:CHEMBL1540129
Mol file:28799-82-8.mol

Synonyms:28799-82-8;1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile;2-hydroxy-1-(2-hydroxyethyl)-4-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile;6-Hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;2-hydroxy-1-(2-hydroxyethyl)-4-methyl-6-oxopyridine-3-carbonitrile;202118-74-9;6-Hydroxy-1-(2-hydroxy-ethyl)-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile;EINECS 249-231-0;Oprea1_473899;Oprea1_524809;MLS000069028;SCHEMBL4801776;CHEMBL1540129;SCHEMBL10352245;DTXSID80951440;HMS2371B20;STK743392;STK869230;AKOS000286771;AKOS000295360;AT19268;SMR000001059;CS-0217476;FT-0769333;EN300-7491994;SR-01000532200;SR-01000532200-1;3-cyano-6-hydroxy4-methyl-1-(2-hydroxyethyl)pyrid-2-one;3-cyano-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2(1h)-pyridinone;2-hydroxy-1-(2-hydroxyethyl)-4-methyl-6-oxo-1,6-dihydro-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxo-;6-Hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile #

Suppliers and Price of 1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile

Chemical Property:

Vapor Pressure:2.34E-07mmHg at 25°C
Boiling Point:380.6°Cat760mmHg
Flash Point:184°C
PSA：86.25000
Density:1.41g/cm³
LogP:-0.27372
XLogP3:-0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:194.06914219
Heavy Atom Count:14
Complexity:373

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)N(C(=C1C#N)O)CCO

Technology Process of 1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile

There total 8 articles about 1,2-Dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 141-43-5
ethanolamine

: 105-45-3
acetoacetic acid methyl ester

: 105-34-0
methyl 2-cyanoacetate

: 28799-82-8
1-(2-hydroxyethyl)-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: With silica gel; for 0.0333333h; microwave irradiation;
DOI:10.1007/s00706-002-0551-2

Reference yield: 59.0%

: 15029-40-0
2-cyano-N-(2-hydroxyethyl)acetamide

: 141-97-9
ethyl acetoacetate

: 28799-82-8
1-(2-hydroxyethyl)-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: With sodium hydroxide; In methanol; water; for 8h; Reflux;
DOI:10.2298/JSC180703092T

Reference yield:

: 141-97-9
ethyl acetoacetate

: 141-43-5
ethanolamine

: 105-34-0
methyl 2-cyanoacetate

: 28799-82-8
1-(2-hydroxyethyl)-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: ethyl acetoacetate; ethanolamine; methyl 2-cyanoacetate; at 95 ℃; for 24h;

With hydrogenchloride; In water; at 20 ℃; for 1h;