[(Z)-1-(4-methoxyphenyl)ethylideneamino]urea

Base Information

• Chemical Name: [(Z)-1-(4-methoxyphenyl)ethylideneamino]urea
• CAS No.: 717-14-6
• Molecular Formula: C10H13 N3 O2
• Molecular Weight: 207.232
• Hs Code.: 2928000090
• NSC Number: 25013
• Nikkaji Number: J899.310F
• Mol file: 717-14-6.mol

Synonyms:[(Z)-1-(4-methoxyphenyl)ethylideneamino]urea;717-14-6;NSC634796;4'-Methoxyacetophenonesemicarbazone;NSC25013;NSC-25013;AKOS000368880;1-(4-Methoxyphenyl)ethanone semicarbazone

Chemical Property of [(Z)-1-(4-methoxyphenyl)ethylideneamino]urea

Chemical Property:

• Melting Point: 200-202°C
• PSA: 76.71000
• Density: 1.19g/cm³
• LogP: 2.17870
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 207.100776666
• Heavy Atom Count: 15
• Complexity: 245

Purity/Quality:

98%min ^*data from raw suppliers

2-[1-(4-Methoxyphenyl)ethylidene]-1-hydrazineCarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NNC(=O)N)C1=CC=C(C=C1)OC
• Isomeric SMILES: C/C(=N/NC(=O)N)/C1=CC=C(C=C1)OC

Technology Process of [(Z)-1-(4-methoxyphenyl)ethylideneamino]urea

There total 5 articles about [(Z)-1-(4-methoxyphenyl)ethylideneamino]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

semicarbazide hydrochloride (563-41-7) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 4-methoxyacetophenone semicarbazone (717-14-6)

Guidance literature:

With ethanol; potassium acetate;

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 4-methoxyacetophenone semicarbazone (717-14-6)

Guidance literature:

DOI:10.1021/ja01204a504 DOI:10.1021/ja01184a101

Reference yield:

methoxybenzene (100-66-3) → 4-methoxyacetophenone semicarbazone (717-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroacetic acid-anhydride / 170 - 180 °C

With Chloroacetic anhydride;

upstream raw materials:

semicarbazide hydrochloride

1-(4-methoxyphenyl)ethanone

methoxybenzene

hydrazine carboxamide

Downstream raw materials:

1-(4-methoxyphenyl)ethanone

Potassium; (4-methoxy-phenyl)-ethyneselenolate

3-(4-Methoxyphenyl)-1H-pyrazole-4-carboxaldehyde

C₂₂H₂₂N₃O₂P

Refernces

• 1、 Liang, Zhaochang,Huang, Yuping,Wang, Shiben,Deng, Xianqing. "Synthesis and biological evaluation of some pyrazole derivatives, containing (Thio) semicarbazide, as dual anti-inflammatory antimicrobial agents". . p. 1020 - 1030. Retrieved 2019/10/28.
• 2、 O'Connor,Sachinvala,Ganjian. "Preparation of 2-Arylethynylselanylacetonitriles from 4-Aryl-1,2,3-selenadiazoles". . p. 1167 - 1169. Retrieved 2015/08/06.