4-Hydroxyphenylbutazone

Base Information

Chemical Name:4-Hydroxyphenylbutazone
CAS No.:16860-43-8
Molecular Formula:C19H20 N2 O3
Molecular Weight:324.379
Hs Code.:2933990090
NSC Number:382672
UNII:R4ROQ243U3
DSSTox Substance ID:DTXSID10168584
Nikkaji Number:J1.713.059E
Wikidata:Q27287792
Mol file:16860-43-8.mol

Synonyms:4-hydroxyphenylbutazone

Suppliers and Price of 4-Hydroxyphenylbutazone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-HydroxyPhenylbutazone
100mg
$ 900.00

Sigma-Aldrich
Phenylbutazone impurity B European Pharmacopoeia (EP) Reference Standard
y0000147
$ 190.00

Total 11 raw suppliers

Chemical Property of 4-Hydroxyphenylbutazone

Chemical Property:

Vapor Pressure:2.41E-09mmHg at 25°C
Boiling Point:462.3°Cat760mmHg
Flash Point:233.4°C
PSA：60.85000
Density:1.256g/cm³
LogP:3.03270
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:324.14739250
Heavy Atom Count:24
Complexity:431

Purity/Quality:

97% ^*data from raw suppliers

4-HydroxyPhenylbutazone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC1(C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)O
Uses Impurity in the production of Phenylbutazone (P319570)

Technology Process of 4-Hydroxyphenylbutazone

There total 11 articles about 4-Hydroxyphenylbutazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 50-33-9,4297-92-1
Phenylbutazone

: 16860-43-8
4-Butyl-4-hydroxy-1,2-diphenyl-1H-pyrazol-3,5(2H,4H)-dion

Guidance literature:: With dihydrogen peroxide; sodium hydrogencarbonate; In water; acetonitrile;
DOI:10.1002/jps.22021

Reference yield: 90.0%

: 33053-06-4
phenylbutazone hydroperoxide

: 16860-43-8
4-Butyl-4-hydroxy-1,2-diphenyl-1H-pyrazol-3,5(2H,4H)-dion

Guidance literature:: With hydrogen; platinum on activated charcoal; In ethanol; at 25 ℃;

Reference yield:

: disodium (4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methyl phosphate

: 16860-43-8
4-Butyl-4-hydroxy-1,2-diphenyl-1H-pyrazol-3,5(2H,4H)-dion

Guidance literature:: Multi-step reaction with 2 steps

1: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction

2: dihydrogen peroxide; sodium hydrogencarbonate / water; acetonitrile

With human placental alkaline phosphatase; dihydrogen peroxide; sodium hydrogencarbonate; magnesium chloride; zinc(II) chloride; In water; acetonitrile;
DOI:10.1002/jps.22021