ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE
• CAS No.: 212770-54-2
• Molecular Formula: C22H27NO5S
• Molecular Weight: 417.526
• Mol file: 212770-54-2.mol

Synonyms:4-(4-methoxybenzenesulfonyl)-1-benzylpiperidine-4-carboxylic acid ethyl ester;1-Benzyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester;4-(4-Methoxy-benzenesulfonyl)-1-benzyl-piperidine-4-carboxylic acid ethyl ester;

Chemical Property of ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE

Chemical Property:

• PSA: 81.29000
• LogP: 4.08550

Purity/Quality:

ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE

There total 4 articles about ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(4-methoxybenzenesulfonyl)acetic acid ethyl ester (2850-21-7) + N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride (10429-82-0) → 4-(4-methoxy-benzenesulfonyl)-1-benzyl-piperidine-4-carboxylic acid ethyl ester (212770-54-2)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 16h; Heating;

DOI:10.1021/jm0205550

Reference yield:

4-Methoxybenzenethiol (696-63-9) → 4-(4-methoxy-benzenesulfonyl)-1-benzyl-piperidine-4-carboxylic acid ethyl ester (212770-54-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / acetone / 8 h / Heating

2: 100 percent / 60 percent MCPBA / CH₂Cl₂ / 6 h / 20 °C

3: 60 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / Heating

With 18-crown-6 ether; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone;

DOI:10.1021/jm0205550

Reference yield:

(4-methoxy-phenylsulfanyl)-acetic acid ethyl ester (28743-98-8) → 4-(4-methoxy-benzenesulfonyl)-1-benzyl-piperidine-4-carboxylic acid ethyl ester (212770-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 60 percent MCPBA / CH₂Cl₂ / 6 h / 20 °C

2: 60 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / Heating

With 18-crown-6 ether; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone;

DOI:10.1021/jm0205550

upstream raw materials:

2-(4-methoxybenzenesulfonyl)acetic acid ethyl ester

N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride

4-Methoxybenzenethiol

(4-methoxy-phenylsulfanyl)-acetic acid ethyl ester

Downstream raw materials:

4-(4-Methoxy-benzenesulfonyl)-1-benzyl-piperidine-4-carboxylic acid

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