4-(2-(N-Acetylamino)ethyl)acetophenone

Base Information

• Chemical Name: 4-(2-(N-Acetylamino)ethyl)acetophenone
• CAS No.: 23279-64-3
• Molecular Formula: C12H15 N O2
• Molecular Weight: 205.257
• Mol file: 23279-64-3.mol

Synonyms:Acetamide,N-(p-acetylphenethyl)- (8CI); 4'-(2-Acetamidoethyl)acetophenone;N-[2-(4-Acetylphenyl)ethyl]acetamide; NSC 41639

Chemical Property of 4-(2-(N-Acetylamino)ethyl)acetophenone

Chemical Property:

• Vapor Pressure: 1.46E-07mmHg at 25°C
• Boiling Point: 428.9°Cat760mmHg
• Flash Point: 182°C
• PSA: 46.17000
• Density: 1.064g/cm³
• LogP: 1.95870

Purity/Quality:

97% ^*data from raw suppliers

N-[2-(4-acetylphenyl)ethyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-(N-Acetylamino)ethyl)acetophenone

There total 2 articles about 4-(2-(N-Acetylamino)ethyl)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl-N-(benzyl-methyl)-formamide (877-95-2) + acetyl chloride (75-36-5) → N-[2-(4-acetylphenyl)ethyl]acetamide (23279-64-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2007.06.072

Reference yield:

Acetyl bromide (506-96-7) + methyl-N-(benzyl-methyl)-formamide (877-95-2) → N-[2-(4-acetylphenyl)ethyl]acetamide (23279-64-3)

Guidance literature:

With aluminium trichloride; 1,1,2,2-tetrachloroethane;

DOI:10.1021/ja01252a036

Reference yield: 83.0%

N-[2-(4-acetylphenyl)ethyl]acetamide (23279-64-3) → N-[2-(4-bromoacetyl-phenyl)-ethyl]-acetamide (416860-02-1)

Guidance literature:

With tetra-N-butylammonium tribromide; In methanol; dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/j.bmcl.2007.06.072

upstream raw materials:

Acetyl bromide

methyl-N-(benzyl-methyl)-formamide

acetyl chloride

Downstream raw materials:

4-(2-acetamidoethyl)benzoic acid

N-[2-(4-bromoacetyl-phenyl)-ethyl]-acetamide

4-(2-aminoethyl)benzoic acid

4-<2-(acetamido)ethyl>-acetanilide