Unii-M7ias8PR23

Base Information

Chemical Name:Unii-M7ias8PR23
CAS No.:216252-56-1
Molecular Formula:C22H34N4O3
Molecular Weight:402.537
Hs Code.:
UNII:M7IAS8PR23
Nikkaji Number:J1.324.288G
Pharos Ligand ID:P4YTBL3F5C4V
ChEMBL ID:CHEMBL275469
Mol file:216252-56-1.mol

Synonyms:RWJ 38063;RWJ-38063

Suppliers and Price of Unii-M7ias8PR23

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Unii-M7ias8PR23

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:402.26309096
Heavy Atom Count:29
Complexity:534

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)OC1=CC=CC=C1N2CCN(CC2)CCNC(=O)CN3CCCCC3=O

Technology Process of Unii-M7ias8PR23

There total 5 articles about Unii-M7ias8PR23 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 72253-28-2
2-(2-oxopiperidin-1-yl)acetic acid

: 216252-68-5
2-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-ethylamine

: 216252-56-1
RWJ 38063

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00169-4

Reference yield:

: 675-20-7
piperidin-2-one

: 216252-56-1
RWJ 38063

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / toluene / 1 h / 0 °C

1.2: 100 percent / 10 h / 20 °C

2.1: 92 percent / TFA / CH₂Cl₂ / 4 h

3.1: 78 percent / EDCI; HOBt; DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; toluene; 1.1: Metallation / 1.2: Alkylation / 2.1: deprotection / 3.1: Acylation;
DOI:10.1016/S0960-894X(00)00169-4

Reference yield:

: 54013-91-1
2-(1-methylethoxy)phenyl-1-piperazine

: 216252-56-1
RWJ 38063

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / K₂CO₃ / acetonitrile / 12 h / Heating

2: methylhydrazine / ethanol / 3 h / Heating

3: 78 percent / EDCI; HOBt; DMAP / CH₂Cl₂ / 20 °C

With dmap; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methylhydrazine; In ethanol; dichloromethane; acetonitrile; 1: Alkylation / 2: deprotection / 3: Acylation;
DOI:10.1016/S0960-894X(00)00169-4