(-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate

Base Information

Chemical Name:(-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate
CAS No.:218614-13-2
Molecular Formula:C20H44O4Si2
Molecular Weight:404.738
Hs Code.:
DSSTox Substance ID:DTXSID90450676
Wikidata:Q82270484
Mol file:218614-13-2.mol

Synonyms:218614-13-2;(-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate;Methyl (3S)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2,2-dimethylpentanoate;FT-0671561;DTXSID90450676;HYLBEYMVUAJSHM-INIZCTEOSA-N

Suppliers and Price of (-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(-)-Methyl(3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate
500mg
$ 100.00

Total 2 raw suppliers

Chemical Property of (-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate

Chemical Property:

PSA：44.76000
LogP:5.98790
Solubility.:Dichloromethane, Ether, Ethyl Acetate, Hexane
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:11
Exact Mass:404.27781295
Heavy Atom Count:26
Complexity:471

Purity/Quality:

99% ^*data from raw suppliers

(-)-Methyl(3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCCC(C(C)(C)C(=O)OC)O[Si](C)(C)C(C)(C)C
Isomeric SMILES:CC(C)(C)[Si](C)(C)OCC[C@@H](C(C)(C)C(=O)OC)O[Si](C)(C)C(C)(C)C
Uses (-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate (cas# 218614-13-2) is a compound useful in organic synthesis.

Technology Process of (-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate

There total 10 articles about (-)-Methyl (3S)-3,5-Bis-{[tert-butyldimethylsilyl)oxy]}-2,2-dimethylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 263900-32-9
(+)-methyl (3S)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxy-2,2-dimethylpentanoate

: 218614-13-2
(-)-methyl (3S)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpentanoate

Guidance literature:: With polystyrene-NEt₂; In dichloromethane; at 0 - 20 ℃; for 2.75h;
DOI:10.1002/anie.200351413

Reference yield: 100.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 725738-70-5
(+/-)-methyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-2,2-dimethylpentanoate

: 218614-13-2
(-)-methyl (3S)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpentanoate

Guidance literature:: With diethylamino-polystyrene; In dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1002/chem.200305669

Reference yield:

: 89922-82-7
3-(tert-butyldimethylsilanyloxy)propionaldehyde

: 218614-13-2
(-)-methyl (3S)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / BH₃*THF / tetrahydrofuran / 0.25 h / 20 °C

2: 100 percent / diethylamino-polystyrene / CH₂Cl₂ / 2.5 h / 0 °C

With borane-THF; diethylamino-polystyrene; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200305669