cis-1,4-Bis(acetamidomethyl)cyclohexane

Base Information

• Chemical Name: cis-1,4-Bis(acetamidomethyl)cyclohexane
• CAS No.: 70924-83-3
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.319
• NSC Number: 172319
• DSSTox Substance ID: DTXSID90305879
• Nikkaji Number: J542.935H,J542.937D
• ChEMBL ID: CHEMBL3120733
• Mol file: 70924-83-3.mol

Synonyms:70924-83-3;NSC172319;CHEMBL3120733;SCHEMBL13165688;DTXSID90305879;GUHHUMFYAACNTR-HAQNSBGRSA-N;GUHHUMFYAACNTR-TXEJJXNPSA-N;NSC-172319;cis-1,4-Bis(acetamidomethyl)cyclohexane;trans-1,4-Bis(acetamidomethyl)cyclohexane;N,N'-[Cyclohexane-1,4-diylbis(methylene)]diacetamide;N-((4-[(Acetylamino)methyl]cyclohexyl)methyl)acetamide #;Acetamide, N,N'-[1,4-cyclohexanediylbis(methylene)]bis-, cis-;Acetamide, N,N'-[1,4-cyclohexanediylbis(methylene)]bis-, trans-

Chemical Property of cis-1,4-Bis(acetamidomethyl)cyclohexane

Chemical Property:

• Boiling Point: 477.5°Cat760mmHg
• Flash Point: 194.1°C
• Density: 0.999g/cm³
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 226.168127949
• Heavy Atom Count: 16
• Complexity: 219

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC1CCC(CC1)CNC(=O)C

Technology Process of cis-1,4-Bis(acetamidomethyl)cyclohexane

There total 5 articles about cis-1,4-Bis(acetamidomethyl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-cyclohexane-1,4-dicarbonitrile (6550-96-5) → cis-1,4-bis-acetylaminomethyl-cyclohexane (70924-83-3)

Guidance literature:

With acetic anhydride; platinum; Hydrogenation;

Reference yield:

cis-cyclohexane-1,4-dicarboxylic acid (619-81-8) → cis-1,4-bis-acetylaminomethyl-cyclohexane (70924-83-3)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride

2: aqueous ammonia

3: thionyl chloride

4: platinum; acetic acid anhydride / Hydrogenation

With ammonium hydroxide; thionyl chloride; acetic anhydride; platinum;

Reference yield:

(1s,4s)-cyclohexane-1,4-dicarbonyl dichloride (14571-47-2) → cis-1,4-bis-acetylaminomethyl-cyclohexane (70924-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous ammonia

2: thionyl chloride

3: platinum; acetic acid anhydride / Hydrogenation

With ammonium hydroxide; thionyl chloride; acetic anhydride; platinum;

upstream raw materials:

cis-cyclohexane-1,4-dicarbonitrile

cis-cyclohexane-1,4-dicarboxylic acid

(1s,4s)-cyclohexane-1,4-dicarbonyl dichloride

cis-cyclohexane-dicarboxylic acid-(1.4)-diamide

Downstream raw materials:

cis-cyclohexane-1,4-diyldimethanamine

cis-1,4-bis-benzaminomethyl-cyclohexane