tert-butyloxycarbonyl-leucylphenylalanine methyl ester

Base Information

• Chemical Name: tert-butyloxycarbonyl-leucylphenylalanine methyl ester
• CAS No.: 5874-73-7
• Molecular Formula: C₂₁H₃₂N₂O₅
• Molecular Weight: 392.495
• Mol file: 5874-73-7.mol

Synonyms:tert-butyloxycarbonyl-leucylphenylalanine methyl ester

Chemical Property of tert-butyloxycarbonyl-leucylphenylalanine methyl ester

Chemical Property:

• Vapor Pressure: 4.15E-12mmHg at 25°C
• Melting Point: 185-190℃
• Boiling Point: 549.1°Cat760mmHg
• PKA: 11.34±0.46(Predicted)
• Flash Point: 285.9°C
• PSA: 100.71000
• Density: 1.091g/cm³
• LogP: 3.87100

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl2-((S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-3-phenylpropanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyloxycarbonyl-leucylphenylalanine methyl ester

There total 19 articles about tert-butyloxycarbonyl-leucylphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + N-tert-butoxycarbonyl-L-leucine monohydrate (200937-21-9) → (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester (15136-32-0,87976-66-7,120342-25-8,5874-73-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.12.032

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester (15136-32-0,87976-66-7,120342-25-8,5874-73-7)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.07.017

Reference yield: 98.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester (15136-32-0,87976-66-7,120342-25-8,5874-73-7)

Guidance literature:

With 4-methyl-morpholine; In methanol; at 20 ℃; for 24h;

DOI:10.1248/cpb.55.825

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

methyl (2S)-2-amino-3-phenylpropanoate

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

(S)-benzyl 2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-3-phenylpropanoate

Downstream raw materials:

Boc-Leu-Phe-Val-NH₂

Boc-(L)-Leu-ψ(CSNH)-(L)-Phe-OMe

Boc-Leu-Phe-NHNH₂

Boc-Leu-Phe-OC₃H₇-i

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