COLLISMYCIN A

Base Information

Chemical Name:COLLISMYCIN A
CAS No.:158792-24-6
Molecular Formula:C₁₃H₁₃N₃O₂S
Molecular Weight:275.331
Hs Code.:2933399090
Mol file:158792-24-6.mol

Synonyms:[2,2'-Bipyridine]-6-carboxaldehyde,4-methoxy-5-(methylthio)-, oxime, (E)- (9CI); Collismycin A; SF 2738A

Suppliers and Price of COLLISMYCIN A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehydeoxime 95+%
1g
$ 880.00

Chemenu
(E)-4-methoxy-5-(methylthio)-[2,2''-bipyridine]-6-carbaldehydeoxime 95%
1g
$ 830.00

Cayman Chemical
Collismycin A
5mg
$ 975.00

Cayman Chemical
Collismycin A
1mg
$ 325.00

American Custom Chemicals Corporation
COLLISMYCIN A 95.00%
1G
$ 1575.00

American Custom Chemicals Corporation
COLLISMYCIN A 95.00%
5MG
$ 499.39

Total 10 raw suppliers

Chemical Property of COLLISMYCIN A

Chemical Property:

Vapor Pressure:5.16E-06mmHg at 25°C
Melting Point:173-174 °C
Boiling Point:381.2 °C at 760 mmHg
PKA:9.75±0.50(Predicted)
Flash Point:184.3 °C
PSA：92.90000
Density:1.27 g/cm³
LogP:2.68220
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehydeoxime 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues. Collismycin A is a microbial product that exhibits anti-proliferative activity against cancer cells. Collismycin A is also an iron chelator and used to develop neuroprotective compounds.

Technology Process of COLLISMYCIN A

There total 16 articles about COLLISMYCIN A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 205053-07-2
4-methoxy-5-methylsulfanyl-[2,2′]bipyridinyl-6-carbaldehyde

: 158792-24-6,158792-25-7
collismycin A

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 50 - 55 ℃; for 1h;
DOI:10.1021/op3003129

Reference yield:

: 98-98-6
2-Picolinic acid

: 158792-24-6,158792-25-7
collismycin A

Guidance literature:: With Streptomyces CLM-L mutant; at 30 ℃; for 144h;
DOI:10.1016/j.bmcl.2013.08.017

Reference yield:

: 33421-43-1
2,2'-bipyridyl N-oxide

: 158792-24-6,158792-25-7
collismycin A

Guidance literature:: Multi-step reaction with 7 steps

1.1: 65 percent / KNO₃; H₂SO₄ / 2.5 h / 110 °C

2.1: 88 percent / methanol / 0.5 h / 40 °C

3.1: LDA / hexane; tetrahydrofuran / 1 h / -70 °C

3.2: 15 percent / BrCN / hexane; tetrahydrofuran / 0.25 h / -70 °C

4.1: 90 percent / PBr₃ / CHCl₃ / 0.75 h / Heating

5.1: LDA / tetrahydrofuran; hexane / 1 h / -70 °C

5.2: 61 percent / tetrahydrofuran; hexane / -70 - 20 °C

6.1: TMEDA; BuLi / diethyl ether; hexane / 0.5 h / -70 °C

6.2: 55 percent / diethyl ether; hexane / 0.75 h / -70 - -30 °C

7.1: 71 percent / hydroxylamine hydrochloride; pyridine / ethanol / 1 h / Heating

With pyridine; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; hydroxylamine hydrochloride; phosphorus tribromide; potassium nitrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; chloroform; 1.1: Nitration / 2.1: Substitution / 3.1: Metallation / 3.2: Bromination / 4.1: Reduction / 5.1: Metallation / 5.2: Oxidation / 6.1: Metallation / 6.2: Formylation / 7.1: Condensation;
DOI:10.1021/jo972022i