Propanamide, N-(3-bromo-2-pyridinyl)-2,2-dimethyl-

Base Information

Chemical Name:Propanamide, N-(3-bromo-2-pyridinyl)-2,2-dimethyl-
CAS No.:239137-57-6
Molecular Formula:C10H13BrN2O
Molecular Weight:257.13
Hs Code.:
Mol file:239137-57-6.mol

Synonyms:N-(3-bromopyridine-2-yl)-2,2-dimethylpropionamide;N-(3-BROMO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE;3-Bromo-2-(2,2-dimethylpropanoylamino)pyridine;N-(3-bromo-2-pyridyl)-2,2-dimethylpropanamide;N-(3-BROMOPYRIDIN-2-YL)PIVALAMIDE;N-t-butylcarbonyl-bromo-pyridyl-2-amine;N1-(3-Bromo-2-pyridyl)-2,2-dimethylpropanamide;

Suppliers and Price of Propanamide, N-(3-bromo-2-pyridinyl)-2,2-dimethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemSupplyAustralia
N-?(3-?Bromo-?2-?pyridinyl)?-?2,?2-?dimethylpropanamide, 97%
1 g
$ 495.00

ChemSupplyAustralia
N-?(3-?Bromo-?2-?pyridinyl)?-?2,?2-?dimethylpropanamide, 97%
250 mg
$ 181.50

Total 2 raw suppliers

Chemical Property of Propanamide, N-(3-bromo-2-pyridinyl)-2,2-dimethyl-

Chemical Property:

Boiling Point:374.8±27.0 °C(Predicted)
PSA：45.48000
Density:1.416±0.06 g/cm3(Predicted)
LogP:3.47820

Purity/Quality:

98%min ^*data from raw suppliers

N-?(3-?Bromo-?2-?pyridinyl)?-?2,?2-?dimethylpropanamide, 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Propanamide, N-(3-bromo-2-pyridinyl)-2,2-dimethyl-

There total 5 articles about Propanamide, N-(3-bromo-2-pyridinyl)-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 86847-59-8
2-(pivaloylamino)pyridine

: 239137-57-6
N-(3-bromopyridin-2-yl)-2,2-dimethylpropanamide

Guidance literature:: 2-(pivaloylamino)pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -30 - 0 ℃; for 5h;

With 1,1-Dibromoethane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Further stages.;
DOI:10.1016/j.tet.2007.07.028

Reference yield: 80.0%

: 13534-99-1
2-Amino-3-bromopyridine

: 3282-30-2
pivaloyl chloride

: 239137-57-6
N-(3-bromopyridin-2-yl)-2,2-dimethylpropanamide

Guidance literature:: In pyridine; at 10 ℃; for 1h;
DOI:10.1055/s-2003-41052

Reference yield:

: 504-29-0
2-aminopyridine

: 239137-57-6
N-(3-bromopyridin-2-yl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: TEA / CH₂Cl₂ / 1 h / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 5 h / -30 - 0 °C

2.2: 81 percent / dibromoethane / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

With n-butyllithium; TEA; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2007.07.028