4-Methyl-N-[1-(4-methylphenyl)but-3-en-1-yl]benzene-1-sulfonamide

Base Information

• Chemical Name: 4-Methyl-N-[1-(4-methylphenyl)but-3-en-1-yl]benzene-1-sulfonamide
• CAS No.: 243671-17-2
• Molecular Formula: C18H21NO2S
• Molecular Weight: 315.436
• DSSTox Substance ID: DTXSID70572608
• Nikkaji Number: J1.159.896J
• Mol file: 243671-17-2.mol

Synonyms:243671-17-2;DTXSID70572608;4-Methyl-N-[1-(4-methylphenyl)but-3-en-1-yl]benzene-1-sulfonamide

Chemical Property of 4-Methyl-N-[1-(4-methylphenyl)but-3-en-1-yl]benzene-1-sulfonamide

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 315.12930009
• Heavy Atom Count: 22
• Complexity: 438

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(CC=C)NS(=O)(=O)C2=CC=C(C=C2)C

Technology Process of 4-Methyl-N-[1-(4-methylphenyl)but-3-en-1-yl]benzene-1-sulfonamide

There total 14 articles about 4-Methyl-N-[1-(4-methylphenyl)but-3-en-1-yl]benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

allyl bromide (106-95-6) + N-[(benzotriazol-1-yl)-p-tolylmethyl]-p-toluenesulfonamide (188564-49-0) → 4-methyl-N-(1-p-tolylbut-3-enyl)benzenesulfonamide (243671-17-2)

Guidance literature:

allyl bromide; With samarium; iodine; In tetrahydrofuran; at 20 ℃; for 1h;

N-[(benzotriazol-1-yl)-p-tolylmethyl]-p-toluenesulfonamide; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1081/SCC-120024744

Reference yield: 95.0%

(E)-N-4-methylbenzylidene-4-toluenesulfonamide (75159-10-3) + potassium trifluoro(prop-1-en-2-yl)borate → 4-methyl-N-(1-p-tolylbut-3-enyl)benzenesulfonamide (243671-17-2)

Guidance literature:

resorcinolbis[(diphenyl)phosphinite] palladium trifluoroacetate; In N,N-dimethyl-formamide; at 40 ℃; for 24h;

DOI:10.1021/ol0475010

Reference yield: 94.0%

allyltributylstanane (24850-33-7) + (E)-N-4-methylbenzylidene-4-toluenesulfonamide (75159-10-3) → 4-methyl-N-(1-p-tolylbut-3-enyl)benzenesulfonamide (243671-17-2)

Guidance literature:

With (tetrabutylammonium)_4.4(dimethylammonium)_0.6C₁₁H₁₂N₂PdP₂V₃W₁₅O₆₂; In N,N-dimethyl-formamide; at 40 ℃; for 1h; Catalytic behavior; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ol501644c

upstream raw materials:

4-methyl-benzaldehyde

toluene-4-sulfonamide

allyl-trimethyl-silane

N-(4-methylbenzylidene)-p-toluenesulfonamide

Downstream raw materials:

N-(4-methylbenzylidene)-p-toluenesulfonamide