N-(4-BroMo-benzyl)-2-chloro-acetaMide

Base Information

• Chemical Name: N-(4-BroMo-benzyl)-2-chloro-acetaMide
• CAS No.: 24942-06-1
• Molecular Formula: C9H9BrClNO
• Molecular Weight: 262.534
• Mol file: 24942-06-1.mol

Synonyms:N-(4-bromobenzyl)-2-chloroacetamide;N-(4-Bromo-benzyl)-2-chloro-acetamide;

Chemical Property of N-(4-BroMo-benzyl)-2-chloro-acetaMide

Chemical Property:

• Boiling Point: 426.1±35.0 °C(Predicted)
• PKA: 13.39±0.46(Predicted)
• PSA: 29.10000
• Density: 1.524±0.06 g/cm3(Predicted)
• LogP: 2.69500

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-BroMo-benzyl)-2-chloro-acetaMide

There total 3 articles about N-(4-BroMo-benzyl)-2-chloro-acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-bromobenzenemethanol (873-75-6) + chloroacetonitrile (107-14-2) → N-((4-bromophenyl)methyl)-2-chloroethanamide (24942-06-1)

Guidance literature:

With silica-bonded N-propylsulphamic acid; In neat (no solvent); at 80 ℃; for 1.5h; Green chemistry;

DOI:10.1007/s12039-012-0309-2

Reference yield: 58.0%

4-Bromobenzylamine (3959-07-7) + chloroacetyl chloride (79-04-9) → N-((4-bromophenyl)methyl)-2-chloroethanamide (24942-06-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1021/jo0478297

Reference yield: 47.5%

→ N-((4-bromophenyl)methyl)-2-chloroethanamide (24942-06-1)

Guidance literature:

With pyridine; In water; at 0 ℃; for 1h; Cooling with ice;

upstream raw materials:

4-Bromobenzylamine

chloroacetyl chloride

4-bromobenzenemethanol

chloroacetonitrile

Downstream raw materials:

1-((4-bromophenyl)methylcarbamoylmethyl)-4,7,10-tris(tret-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

Refernces

• 1、 Li, Qiu,Chen, Peng,Yang, Haikui,Luo, Miaolan,You, Wenwei,Zhao, Peiliang. "Synthesis, antiproliferative evaluation, and structure–activity relationships of novel triazole–isoindoline hybrids bearing 3,4,5-trimethoxyphenyl moiety". . p. 651 - 659. Retrieved 2018/02/28.
• 2、 -. "4-aminoacylphenoxyacetamide compound and medicine uses thereof". Paragraph 0053; 0054; 0055; 0061; 0062; 0063; 0064. . Retrieved 2016/10/08.