2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide

Base Information

Chemical Name:2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide
CAS No.:252580-25-9
Molecular Formula:C₁₁H₁₂F₃NO
Molecular Weight:231.218
Hs Code.:
DSSTox Substance ID:DTXSID80591986
Wikidata:Q82485868
Mol file:252580-25-9.mol

Synonyms:252580-25-9;2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide;SCHEMBL3533532;DTXSID80591986;AKOS013916574

Suppliers and Price of 2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:231.08709849
Heavy Atom Count:16
Complexity:252

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=CC(=C(C(=C1)F)F)F

Technology Process of 2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide

There total 1 articles about 2,2-Dimethyl-N-(3,4,5-trifluorophenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3282-30-2
pivaloyl chloride

: 163733-96-8
3,4,5-trifluoro aniline

: 252580-25-9
2,2-dimethyl-N-(3,4,5-trifluorophenyl)-propionamide

Guidance literature:: With TEA; In dichloromethane; at 0 - 25 ℃; for 3h;
DOI:10.1016/S0960-894X(99)00486-2

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: 252580-25-9
2,2-dimethyl-N-(3,4,5-trifluorophenyl)-propionamide

: 2,2-Dimethyl-N-[3,4,5-trifluoro-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

Guidance literature:: 2,2-dimethyl-N-(3,4,5-trifluorophenyl)-propionamide; With n-butyllithium; In tetrahydrofuran; at -40 ℃; for 1h;

ethyl trifluoroacetate,; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00486-2

Reference yield:

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 252580-25-9
2,2-dimethyl-N-(3,4,5-trifluorophenyl)-propionamide

: 850564-07-7
4,5,6-trifluoro-2-N-pivaloylaminobenzaldehyde

Guidance literature:: 2,2-dimethyl-N-(3,4,5-trifluorophenyl)-propionamide; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -70 ℃; for 1h;