4-(5-Fluoro-2-methoxyphenyl)piperidine

Base Information

• Chemical Name: 4-(5-Fluoro-2-methoxyphenyl)piperidine
• CAS No.: 255893-55-1
• Molecular Formula: C12H16FNO
• Molecular Weight: 209.264
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00573522
• Wikidata: Q82462259
• Mol file: 255893-55-1.mol

Synonyms:4-(5-Fluoro-2-methoxyphenyl)piperidine;255893-55-1;4-(5-fluoro-2-methoxy-phenyl)-piperidine;SCHEMBL5020026;DTXSID00573522;VSOZYVHMRRLERD-UHFFFAOYSA-N;AKOS013782102;EN300-1171884;4-(5-Fluoro-2-methoxyphenyl)piperidine, AldrichCPR

Chemical Property of 4-(5-Fluoro-2-methoxyphenyl)piperidine

Chemical Property:

• PSA: 21.26000
• LogP: 2.63010
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 209.121592296
• Heavy Atom Count: 15
• Complexity: 194

Purity/Quality:

4-(5-FLUORO-2-METHOXYPHENYL)PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)F)C2CCNCC2

Technology Process of 4-(5-Fluoro-2-methoxyphenyl)piperidine

There total 8 articles about 4-(5-Fluoro-2-methoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.1%

→ 4-(5-fluoro-2-methoxy-phenyl)-piperidine (255893-55-1)

Guidance literature:

Reference yield: 44.0%

4-(5-fluoro-2-methoxyphenyl)-piperidine-1-carboxylic acid t-butyl ester → 4-(5-fluoro-2-methoxy-phenyl)-piperidine (255893-55-1)

Guidance literature:

With hydrogenchloride; In methanol; isopropyl alcohol; at 20 ℃; for 1.5h;

DOI:10.1021/jm300912k

Reference yield:

1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine → 4-(5-fluoro-2-methoxy-phenyl)-piperidine (255893-55-1)

Guidance literature:

In hydrogenchloride;

upstream raw materials:

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

2-bromo-4-fluoro-1-methoxybenzene

Downstream raw materials:

[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazine

3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]-pyridin-7-yl]-4-piperidinyl]-4-fluoro-phenol

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