8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Base Information

Chemical Name:8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine
CAS No.:1254977-90-6
Molecular Formula:C₂₂H₂₄ClFN₄O
Molecular Weight:414.91
Hs Code.:

Synonyms:8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

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Chemical Property of 8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

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Technology Process of 8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

There total 11 articles about 8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 255893-55-1
4-(5-fluoro-2-methoxy-phenyl)-piperidine

: 1254981-17-3
8-chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine

: 1254977-90-6
8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; at 180 ℃; Sealed tube;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1254977-90-6
8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

3: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

4: sodium hydrogencarbonate / acetonitrile / 180 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm300912k

Reference yield:

: 452-08-4
2-bromo-4-fluoro-1-methoxybenzene

: 1254977-90-6
8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

3: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

4: sodium hydrogencarbonate / acetonitrile / 180 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm300912k