8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

Base Information

Chemical Name:8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine
CAS No.:1254978-05-6
Molecular Formula:C₂₀H₁₉ClF₄N₄O
Molecular Weight:442.844
Hs Code.:

Synonyms:8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

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Chemical Property of 8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

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Technology Process of 8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

There total 12 articles about 8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.5%

: 1376335-41-9
3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

: 1254978-05-6
8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: 3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide; With trichlorophosphate; In acetonitrile; at 160 ℃; Microwave irradiation;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 1376335-40-8
[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazine

: 1254978-05-6
8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: trichlorophosphate / acetonitrile / 160 °C / Microwave irradiation

With triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;

Reference yield:

: 1376335-39-5
2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

: 1254978-05-6
8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)-1-piperidinyl]-3-(2,2,2-trifluoroethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol; water / 0.75 h / 160 °C / Microwave irradiation

2: triethylamine / dichloromethane / 0 - 20 °C

3: trichlorophosphate / acetonitrile / 160 °C / Microwave irradiation

With hydrazine hydrate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; acetonitrile;