2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Base Information

Chemical Name:2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl
CAS No.:1376335-39-5
Molecular Formula:C₁₇H₁₇Cl₂FN₂O
Molecular Weight:355.239
Hs Code.:

Synonyms:2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

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Chemical Property of 2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

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Technology Process of 2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

There total 7 articles about 2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.5%

: 255893-55-1
4-(5-fluoro-2-methoxy-phenyl)-piperidine

: 889865-45-6
2,3-dichloro-4-iodopyridine

: 1376335-39-5
2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 110 ℃;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1376335-39-5
2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

3: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 110 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm300912k

Reference yield:

: 4-(5-fluoro-2-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1376335-39-5
2',3'-dichloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

Guidance literature:: Multi-step reaction with 3 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

2: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 110 °C

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm300912k