4-(3,4-Dichlorophenyl)-1-methylpiperidine-4-carbonitrile

Base Information

Chemical Name:4-(3,4-Dichlorophenyl)-1-methylpiperidine-4-carbonitrile
CAS No.:258500-84-4
Molecular Formula:C13H14Cl2N2
Molecular Weight:269.174
Hs Code.:
ChEMBL ID:CHEMBL113336
DSSTox Substance ID:DTXSID50460317
Nikkaji Number:J1.222.577F
Wikidata:Q82284325
Mol file:258500-84-4.mol

Synonyms:CHEMBL113336;4-(3,4-dichlorophenyl)-1-methylpiperidine-4-carbonitrile;258500-84-4;SCHEMBL4656597;DTXSID50460317;JKTMKXOTSKFHNA-UHFFFAOYSA-N;BDBM50083526;1-N-methyl-4-(3,4-dichlorophenyl)-4-cyanopiperidine;4-(3,4-Dichloro-phenyl)-1-methyl-piperidine-4-carbonitrile

Suppliers and Price of 4-(3,4-Dichlorophenyl)-1-methylpiperidine-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,4-Dichlorophenyl)-1-methylpiperidine-4-carbonitrile

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:268.0534038
Heavy Atom Count:17
Complexity:315

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(CC1)(C#N)C2=CC(=C(C=C2)Cl)Cl

Technology Process of 4-(3,4-Dichlorophenyl)-1-methylpiperidine-4-carbonitrile

There total 4 articles about 4-(3,4-Dichlorophenyl)-1-methylpiperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 258500-84-4
4-(3,4-dichlorophenyl)-1-methylpiperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NaNH₂ / toluene / Heating

2: aq. HCl / 50 °C

3: 0.79 g / NaBH₃CN / methanol / 48 h

With hydrogenchloride; sodium cyanoborohydride; sodium amide; In methanol; toluene;
DOI:10.1021/jm0401614

Reference yield:

: 258500-77-5
2-(3,4-dichlorophenyl)-2-(2,2-dimethoxyethyl)-4,4-dimethoxybutyronitrile

: 258500-84-4
4-(3,4-dichlorophenyl)-1-methylpiperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / 50 °C

2: 0.79 g / NaBH₃CN / methanol / 48 h

With hydrogenchloride; sodium cyanoborohydride; In methanol;
DOI:10.1021/jm0401614