1,2-Ethanediol, 1-(2,3,5-trimethoxy-4-methylphenyl)-, (1S)-

Base Information

Chemical Name:1,2-Ethanediol, 1-(2,3,5-trimethoxy-4-methylphenyl)-, (1S)-
CAS No.:271578-79-1
Molecular Formula:C12H18O5
Molecular Weight:242.272
Hs Code.:

Synonyms:

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Chemical Property of 1,2-Ethanediol, 1-(2,3,5-trimethoxy-4-methylphenyl)-, (1S)-

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Technology Process of 1,2-Ethanediol, 1-(2,3,5-trimethoxy-4-methylphenyl)-, (1S)-

There total 8 articles about 1,2-Ethanediol, 1-(2,3,5-trimethoxy-4-methylphenyl)-, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 271578-78-0
1,3,4-trimethoxy-2-methyl-5-vinylbenzene

: 271578-79-1
(S)-1-(2,3,5-Trimethoxy-4-methyl-phenyl)-ethane-1,2-diol

Guidance literature:: With AD-mix-α; In water; tert-butyl alcohol; at 0 ℃; for 72h;
DOI:10.1016/S0040-4039(00)00105-2

Reference yield:

: 85071-59-6
1-bromo-2,3,5-trimethoxy-4-methylbenzaldehyde

: 271578-79-1
(S)-1-(2,3,5-Trimethoxy-4-methyl-phenyl)-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / tetrahydrofuran / 1 h / 0 °C

2: 99 percent / AD-mix-α / 2-methyl-propan-2-ol; H2O / 72 h / 0 °C

With AD-mix-α; In tetrahydrofuran; water; tert-butyl alcohol; 1: Condensation / 2: dihydroxylation;
DOI:10.1016/S0040-4039(00)00105-2

Reference yield:

: 60512-80-3
2′,4′-dimethoxy-3′-methylacetophenone

: 271578-79-1
(S)-1-(2,3,5-Trimethoxy-4-methyl-phenyl)-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17.5 h / 0 - 20 °C / Inert atmosphere

2.1: water; potassium carbonate / methanol / 16 h / 20 °C / Inert atmosphere

3.1: bromine; potassium carbonate / dichloromethane / 2 h / -78 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 33 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

5.2: -78 - -10 °C / Inert atmosphere

6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

7.1: AD-mix-α; water / tert-butyl alcohol / 17 h / 0 °C / Inert atmosphere

With n-butyllithium; AD-mix-α; potassium tert-butylate; water; bromine; potassium carbonate; potassium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; 7.1: Sharpless dihydroxylation;
DOI:10.1039/c1cc13992d