2,3,5-Trimethoxy-4-methylbenzaldehyde

Base Information

• Chemical Name: 2,3,5-Trimethoxy-4-methylbenzaldehyde
• CAS No.: 85071-59-6
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• DSSTox Substance ID: DTXSID70448071
• Nikkaji Number: J1.280.978F
• Wikidata: Q82267013
• Mol file: 85071-59-6.mol

Synonyms:2,3,5-Trimethoxy-4-methylbenzaldehyde;85071-59-6;Benzaldehyde, 2,3,5-trimethoxy-4-methyl-;SCHEMBL5146192;DTXSID70448071

Chemical Property of 2,3,5-Trimethoxy-4-methylbenzaldehyde

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 207

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C(=C1OC)OC)C=O)OC

Technology Process of 2,3,5-Trimethoxy-4-methylbenzaldehyde

There total 14 articles about 2,3,5-Trimethoxy-4-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-hydroxy-3,5-dimethoxy-4-methylbenzaldehyde (85071-58-5) + methyl iodide (74-88-4) → 1-bromo-2,3,5-trimethoxy-4-methylbenzaldehyde (85071-59-6)

Guidance literature:

With potassium hydroxide; for 96h; Heating;

DOI:10.1248/cpb.33.2122

Reference yield: 91.0%

2-hydroxy-3,5-dimethoxy-4-methylbenzaldehyde (85071-58-5) + dimethyl sulfate (77-78-1) → 1-bromo-2,3,5-trimethoxy-4-methylbenzaldehyde (85071-59-6)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 40 ℃; for 8h;

Reference yield: 60.0%

1-bromo-2,3,5-trimethoxy-4-methylbenzene (1000880-09-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-bromo-2,3,5-trimethoxy-4-methylbenzaldehyde (85071-59-6)

Guidance literature:

1-bromo-2,3,5-trimethoxy-4-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - -10 ℃; Inert atmosphere;

DOI:10.1039/c1cc13992d

upstream raw materials:

trans-1,3,4-Trimethoxy-2-methyl-5-(1-propenyl)benzol

2-hydroxy-3,5-dimethoxy-4-methylbenzaldehyde

methyl iodide

6-allyl-2,4-dimethoxy-3-methylphenol

Downstream raw materials:

(2,2-Dimethoxy-ethyl)-[1-(2,3,5-trimethoxy-4-methyl-phenyl)-meth-(Z)-ylidene]-amine

2,2-dimethoxy-N-(2,3,5-trimethoxy-4-methylbenzylidene)ethylamine

1,3,4-trimethoxy-2-methyl-5-vinylbenzene

(5,8-dihydro-7-methoxy-6-methyl-5,8-dioxo-1-isoquinolinyl)methyl (2Z)-2-methyl-2-butenoate