2-Ethoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide

Base Information

Chemical Name:2-Ethoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
CAS No.:2716-99-6
Molecular Formula:C18H25N3O2
Molecular Weight:315.41000
Hs Code.:

Synonyms:2-Ethoxy-chinolin-4-carbonsaeure-(2-diethylamino-ethylamid);2-Aethoxy-chinolin-4-carbonsaeure-(2-diaethylamino-aethylamid);2-Ethoxy-chinolin-4-carbonsaeure-diethylethylendiamid;2-Ethoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide;

Suppliers and Price of 2-Ethoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 2-Ethoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide

Chemical Property:

Melting Point:94 - 95 °C
Refractive Index:1.5855 (estimate)
Boiling Point:454.96°C (rough estimate)
PSA：54.46000
Density:1.1345 (rough estimate)
LogP:3.09600
Water Solubility.:208.2mg/L(temperature not stated)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-Ethoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide

There total 7 articles about 2-Ethoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 64-17-5
ethanol

: 87864-14-0
2-chloro-quinoline-4-carboxylic acid-(2-diethylamino-ethylamide)

: 2716-99-6
N-[2-(diethylamino)ethyl]-2-ethoxyquinoline-4-carboxamide

Guidance literature:: ethanol; With sodium hydride; for 0.5h; Inert atmosphere;

2-chloro-quinoline-4-carboxylic acid-(2-diethylamino-ethylamide); With potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112310

Reference yield:

: 2388-32-1
2-chloroquinoline-4-carbonyl chloride

: 2716-99-6
N-[2-(diethylamino)ethyl]-2-ethoxyquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzene

2: ethanol

With ethanol; benzene;

Reference yield:

: 5467-57-2
2-chloroquinoline-4-carboxylic acid

: 2716-99-6
N-[2-(diethylamino)ethyl]-2-ethoxyquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 4 h / 55 °C

2.1: triethylamine / dichloromethane

3.1: sodium hydride / 0.5 h / Inert atmosphere

3.2: 72 h / 80 °C / Inert atmosphere

With thionyl chloride; sodium hydride; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2020.112310