Acetic acid 2,4-dimethoxyphenyl ester

Base Information

• Chemical Name: Acetic acid 2,4-dimethoxyphenyl ester
• CAS No.: 27257-07-4
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2915390090
• Mol file: 27257-07-4.mol

Synonyms:Phenol,2,4-dimethoxy-,acetate;2,4-Dimethoxyphenyl acetate;Acetic acid 2,4-dimethoxyphenyl ester;

Chemical Property of Acetic acid 2,4-dimethoxyphenyl ester

Chemical Property:

• Melting Point: 39 °C
• Boiling Point: 262.8±25.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.120±0.06 g/cm3(Predicted)
• LogP: 1.62910

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid 2,4-dimethoxyphenyl ester

There total 10 articles about Acetic acid 2,4-dimethoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic acid (64-19-7,77671-22-8) + 1,3-Dimethoxybenzene (151-10-0) → 2,4-dimethoxyphenyl acetate (27257-07-4)

Guidance literature:

With sodium nitrate; acetic anhydride; trifluoroacetic acid; at 20 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02183

Reference yield: 66.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + 1,3-Dimethoxybenzene (151-10-0) → 2,4-dimethoxyphenyl acetate (27257-07-4)

Guidance literature:

With gold(III) chloride; In 1,2-dichloro-ethane; at 110 ℃; for 6h; regioselective reaction;

DOI:10.1021/ol202075x

Reference yield: 38.0%

2',4'-dimethoxyacetophenone (829-20-9) → 2,4-dimethoxyphenyl acetate (27257-07-4) + 5-hydroxy-2,4-dimethoxyphenyl acetate

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In acetonitrile; at 80 ℃; for 0.75h; regioselective reaction;

DOI:10.1002/poc.3462

upstream raw materials:

2,4-dimethoxyphenol

acetic anhydride

4-acetoxy-3-methoxyphenol

methyl iodide

Downstream raw materials:

2,4-dimethoxyphenol

1-(5-hydroxy-2,4-dimethoxy-phenyl)-ethanone

5-acetoxy-2,4-dimethoxybenzaldehyde