Phenol, pentafluoro-, 4-nitrobenzoate

Base Information

• Chemical Name: Phenol, pentafluoro-, 4-nitrobenzoate
• CAS No.: 28078-88-8
• Molecular Formula: C13H4F5NO4
• Molecular Weight: 333.171
• Mol file: 28078-88-8.mol

Synonyms:

Chemical Property of Phenol, pentafluoro-, 4-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, pentafluoro-, 4-nitrobenzoate

There total 2 articles about Phenol, pentafluoro-, 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-nitrobenzaldehdye (555-16-8) + (2,3,4,5,6-pentafluorophenyl)pyridine-2-carboxylate (188837-53-8) → 4-nitrobenzoic acid pentafluorophenyl ester (28078-88-8)

Guidance literature:

(2,3,4,5,6-pentafluorophenyl)pyridine-2-carboxylate; With palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In toluene; at 115 ℃; for 0.166667h;

4-nitrobenzaldehdye; With tert.-butylhydroperoxide; In toluene; for 48h; Reflux;

DOI:10.1021/jo3012573

Reference yield: 65.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + 4-nitro-benzoic acid (62-23-7) → 4-nitrobenzoic acid pentafluorophenyl ester (28078-88-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; Ambient temperature;

DOI:10.1016/S0040-4020(97)00149-X

Reference yield: 95.0%

4-nitrobenzoic acid pentafluorophenyl ester (28078-88-8) + N-amino-(4-nitrophenyl)carboxamide (636-97-5) → N,N'-bis-(4-nitro-benzoyl)-hydrazine (4402-22-6)

Guidance literature:

In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4020(97)00149-X

upstream raw materials:

2,3,4,5,6-pentafluorophenol

4-nitro-benzoic acid

4-nitrobenzaldehdye

(2,3,4,5,6-pentafluorophenyl)pyridine-2-carboxylate

Downstream raw materials:

N,N'-bis-(4-nitro-benzoyl)-hydrazine

N-ethyl-4-nitro-N-phenylbenzamide

phenyl 4-nitrobenzoate

Refernces

• 1、 Chen, Jianxia,Namila,Bai, Chaolumen,Baiyin, Menghe,Agula, Bao,Bao, Yong-Sheng. "Transesterification of (hetero)aryl esters with phenols by an Earth-abundant metal catalyst". . p. 25168 - 25176. Retrieved 2018/07/29.
• 2、 Bao, Yong-Sheng,Chen, Chao-Yue,Huang, Zhi-Zhen. "Transesterification for synthesis of carboxylates using aldehydes as acyl donors via C-H and C-O bond activations". . p. 8344 - 8349,6. Retrieved 2020/10/15.