4402-22-6

Usage

Uses

Used in Chemical Synthesis:
1,2-Bis(4-nitrobenzoyl)hydrazine is used as a reagent in the chemical industry for its powerful nucleophilic properties, facilitating the synthesis of a variety of organic compounds and pharmaceuticals.
Used in Pharmaceutical Production:
As a key intermediate in the synthesis of pharmaceuticals, 1,2-Bis(4-nitrobenzoyl)hydrazine contributes to the development of new drugs and medicines.
Used in Fluorescent Dye Production:
1,2-Bis(4-nitrobenzoyl)hydrazine is used as a building block in the production of fluorescent dyes, which have applications in various fields such as bioimaging and diagnostics.
Used in Heterocyclic Compound Synthesis:
1,2-Bis(4-nitrobenzoyl)hydrazine is utilized in the synthesis of heterocyclic compounds, which are important in the creation of complex organic molecules and pharmaceuticals.
Used in Drug Discovery and Development:
Due to its demonstrated biological activity, 1,2-Bis(4-nitrobenzoyl)hydrazine is an important target for further research in drug discovery and development, potentially leading to the creation of new therapeutic agents.

Upstream product

• 110-86-1 pyridine 
• 122-04-3 4-nitro-benzoyl chloride 
• 79-19-6 thiosemicarbazide 
• 28078-88-8 4-nitrobenzoic acid pentafluorophenyl ester 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 76328-74-0 3-(4-nitro-benzoylhydrazono)-butyric acid ethyl ester 
• 62-23-7 4-nitro-benzoic acid 
• 4231-71-4 1H-1,2,3-benzotriazol-1-yl-4-nitrophenylmethanone 
• 33288-81-2 N,N'-(ethane?1,2?diyl)bis(4?nitrobenzamide) 
• 75-05-8 acetonitrile 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 127-09-3 sodium acetate 
• 7803-57-8 hydrazine hydrate 
• 71-43-2 benzene 

Downstream Products

• 1090-82-0 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole 
• 1044-49-1 bis-(4-nitro-phenyl)-[1,3,4]oxadiazole 
• 2642-62-8 4,4'-(1,3,4-thiadiazole-2, 5-diyl)dianiline 
• 37932-42-6 3,6-bis(4-nitrophenyl)-1,2,4,5-tetrazine 
• 53876-69-0 3,6-bis-(4-nitro-phenyl)-1,2-dihydro-[1,2,4,5]tetrazine 
• 51725-77-0 3,5-bis(4-nitrophenyl)-4H-1,2,4-triazole 
• 92061-22-8 2-(4-aminophenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole 
• 5286-77-1 3,5-bis-(4-nitro-phenyl)-4-phenyl-4H-[1,2,4]triazole 

Relevant academic research and scientific papers

Optical detection of sodium salts of fluoride, acetate and phosphate by a diacylhydrazine ligand by the formation of a colour alkali metal complex

A solution of N, N'-diacylhydrazine ligand in organic solvent is potential for colourimetric detection of F-/AcO-/PO 3-4 via -NH deprotonation, tautomerization and its stabilization as a colour alkali metal comp

One-Pot Anodic Conversion of Symmetrical Bisamides of Ethylene Diamine to Unsymmetrical gem-Bisamides of Methylene Diamine

Symmetrical bisamides of ethylene diamine of type ArCONHCH2CH2NHCOAr undergo anodic C-C bond cleavage in acetonitrile-LiClO4 under controlled-potential electrolysis. The electrogenerated carbocation intermediates react with the solvent acetonitrile to afford unsymmetrical gem-bisamides of type ArCONHCH2NHCOMe in a one-pot reaction. The yields of the latter products are moderate (up to 60%). Other minor products involve two symmetrical gem-bisamides of type ArCONHCH2NHCOAr and MeCONHCH2NHCOMe and fragmentation products (e.g., ArCONHCHO, ArCONH2, and ArCN).

Hypochlorite responsive even hydrazide connecting key and application thereof

The invention discloses a hypochlorite responsive even hydrazide connecting key and application thereof. A structural formula of the connecting key is (with the reference to the specification); the connecting key is prepared from an R1 parent containing reactive carbonyl and an R2 parent containing reactive carbonyl by a reaction with hydrazine hydrate; the reactive carbonyl can be ester, carboxylic acid, acyl chloride, aldehyde or cyclic ketone. The connecting key can react with specificity of OCl, is oxidized and cut off by OCl to form carboxyl so as to distinguish OCl in ROS, has high specificity, and can be widely used in various fields of hypochlorite response, such as a hypochlorite fluorescent probe, a hypochlorite responsive drug carrier, a hypochlorite responsive nano probe, a prodrug for treating ROS related diseases, a carrier with double effects of diagnosis and treatment and the like.

Containing 1, 2, 4 - triazole structure diamine compound and its preparation method and application (by machine translation)

The invention discloses a containing 1, 2, 4 - triazole structure diamine compound and its preparation method and application, its first of all through the nitro-substituted benzoyl chlorine and jing prepared by the reaction of the amine intermediate join

Flexible and highly fluorescent aromatic polyimide: design, synthesis, properties, and mechanism

To develop high-performance flexible fluorescent aromatic polyimides and to have a deeper insight into the fluorescence mechanism, two diamine monomers PyDA and TzDA with similar chemical structures but totally different electronic effects, were designed and synthesized. PyDA bears an electron-donor pyrrole group while TzDA bears an electron-acceptor 1,2,4-triazole group. The resulting aromatic polyimide TzODPI containing the triazole group showed bright green photoluminescence with a high quantum yield of up to 61% in solution and 13% in the film state. However, fluorescence was totally quenched in the pyrrole-containing polyimide PyODPI. The completely different phenomena were systematically elucidated with the aid of molecular simulations. Theoretical calculations for the molecular orbital distribution, oscillator strength, and the electron transition process between the ground state and excited state of model molecules were applied to clarify the fluorescence mechanism. Highly fluorescent aromatic polyimides can be obtained by appropriate control of the intra-molecular charge-transfer effects between the diamine and dianhydride moieties, and this demonstrates a simple strategy to develop wholly aromatic polyimides with high fluorescence for potential applications in the field of flexible displays.

Bent Shaped 1,3,4-Oxadiazole/Thiadiazole heterocyclic rings containing liquid crystals

Two series of bent shaped 1,3,4-oxadiazole/thiadiazole heterocyclic ring containing liquid crystalline (LC) compounds were synthesized and characterized by FT-IR, 1H, 13C-NMR and ESI-Mass spectroscopic techniques. Liquid crystal properties were investigated by polarized optical microscopy and differential scanning calorimetry. All the compounds exhibited mesophases such as nematic, smectic A and smectic C phases. The liquid crystalline effects were ascertained by changing the central atom in the heterocyclic ring and by increasing the length of the terminal alkyloxy chains which bring considerable improvements on the mesomorphic properties. The absorption and emission spectral studies of all the compounds were investigated and confirmed.

A general and efficient entry to asymmetric tetrazines for click chemistry applications

The importance of click chemistry is widely recognized. Among all the known click reactions, those involving tetrazines represent the fastest click reactions reported and are generating a great deal of interest. However, there is no efficient entry to asymmetric tetrazines and those with strong electron withdrawing groups, which limits the development of this field. Herein, we report a general and efficient entry to asymmetric tetrazines with strongly electron withdrawing groups.

17O NMR studies of substituted 1,3,4-oxadiazoles

Three series of substituted 1,3,4-oxadiazoles were studied by 17O NMR spectroscopy. Chemical shifts values were correlated with empirical Hammett parameters as well as calculated bond lengths and chemical shielding values.

A convenient and simple transformation of acid hydrazides to N,N′-diacylhydrazines with Hg(OAc)2 under solid state conditions

A highly efficient and practical methodology for the transformation of acid hydrazides 1 to N,N′-diacylhydrazines 2 is described under solid state conditions at RT utilizing inexpensive and easily available reagent Hg(OAc) 2. The products are obtained in good yields with high purity.

A facile synthesis of acylhydrazines from acylbenzotriazoles

Acylbenzotriazoles were found to react with substituted hydrazines and aqueous hydrazine under very mild conditions, thus affording a facile synthesis of three types of acylhydrazines in moderate to excellent yields.